Durotaxis as an elastic stability phenomenon

Lazopoulos, KA; Stamenovic, D

dc.contributor.author	Lazopoulos, KA	en
dc.contributor.author	Stamenovic, D	en
dc.date.accessioned	2014-03-01T01:28:10Z
dc.date.available	2014-03-01T01:28:10Z
dc.date.issued	2008	en
dc.identifier.issn	0021-9290	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18747
dc.subject	Actin stress fibers	en
dc.subject	Cell migration	en
dc.subject	Cytoskeleton	en
dc.subject	Durotaxis	en
dc.subject	Focal adhesions	en
dc.subject	Mathematical modeling	en
dc.subject	Potential	en
dc.subject	Stability	en
dc.subject.classification	Biophysics	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.other	Cell adhesion	en
dc.subject.other	Computer simulation	en
dc.subject.other	Fibers	en
dc.subject.other	Mathematical models	en
dc.subject.other	Stiffness	en
dc.subject.other	Actin stress fibers	en
dc.subject.other	Cell migration	en
dc.subject.other	Durotaxis	en
dc.subject.other	Focal adhesions	en
dc.subject.other	Mathematical modeling	en
dc.subject.other	Cell growth	en
dc.subject.other	actin	en
dc.subject.other	article	en
dc.subject.other	cell migration	en
dc.subject.other	cytoskeleton	en
dc.subject.other	durotaxis	en
dc.subject.other	elasticity	en
dc.subject.other	focal adhesion	en
dc.subject.other	mathematical model	en
dc.subject.other	mechanical stress	en
dc.subject.other	priority journal	en
dc.subject.other	quantitative analysis	en
dc.subject.other	simulation	en
dc.subject.other	stress fiber	en
dc.subject.other	Cell Movement	en
dc.subject.other	Cytoskeleton	en
dc.subject.other	Elasticity	en
dc.subject.other	Focal Adhesions	en
dc.subject.other	Models, Biological	en
dc.subject.other	Stress Fibers	en
dc.title	Durotaxis as an elastic stability phenomenon	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.jbiomech.2008.01.008	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.jbiomech.2008.01.008	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	It is well documented that directed motion of cells is influenced by substrate stiffness. When cells are cultured on a substrate of graded stiffness, they tend to move from softer to stiffer regions-a process known as durotaxis. In this study, we propose a mathematical model of durotaxis described as an elastic stability phenomenon. We model the cytoskeleton (CSK) as a planar system of prestressed elastic line elements representing actin stress fibers (SFs), which are anchored via focal adhesions (FAs) at their end points to an elastic substrate of variable stiffness. The prestress in the SFs exerts a pulling force on FAs reducing thereby their chemical potential. Using Maxwell's global stability criterion, we obtain that the model stability increases as it is moved from a softer towards a stiffer region of the substrate. Numerical simulations reveal that elastic stability of SFs has a predominantly stabilizing effect, greater than the stabilizing effect of decreasing chemical potential of FAs. This is a novel finding which indicates that elasticity of the CSK plays an important role in cell migration and mechanosensing in general. (c) 2008 Elsevier Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI LTD	en
heal.journalName	Journal of Biomechanics	en
dc.identifier.doi	10.1016/j.jbiomech.2008.01.008	en
dc.identifier.isi	ISI:000255674700018	en
dc.identifier.volume	41	en
dc.identifier.issue	6	en
dc.identifier.spage	1289	en
dc.identifier.epage	1294	en