Evidence of a posterior cingulate involvement (Brodmann area 31) in dyslexia: A study based on source localization algorithm of event-related potentials

Stoitsis, J; Giannakakis, GA; Papageorgiou, C; Nikita, KS; Rabavilas, A; Anagnostopoulos, D

dc.contributor.author	Stoitsis, J	en
dc.contributor.author	Giannakakis, GA	en
dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Rabavilas, A	en
dc.contributor.author	Anagnostopoulos, D	en
dc.date.accessioned	2014-03-01T01:28:21Z
dc.date.available	2014-03-01T01:28:21Z
dc.date.issued	2008	en
dc.identifier.issn	0278-5846	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18812
dc.subject	Dyslexia	en
dc.subject	Event-related potentials	en
dc.subject	Genetic algorithms	en
dc.subject	RAP-MUSIC	en
dc.subject	Source localization	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Psychiatry	en
dc.subject.other	protein p50	en
dc.subject.other	adolescent	en
dc.subject.other	article	en
dc.subject.other	cingulate gyrus	en
dc.subject.other	clinical article	en
dc.subject.other	dyslexia	en
dc.subject.other	electroencephalogram	en
dc.subject.other	event related potential	en
dc.subject.other	genetic algorithm	en
dc.subject.other	human	en
dc.subject.other	Kolmogorov Smirnov test	en
dc.subject.other	music	en
dc.subject.other	school child	en
dc.subject.other	Student t test	en
dc.subject.other	Acoustic Stimulation	en
dc.subject.other	Adolescent	en
dc.subject.other	Algorithms	en
dc.subject.other	Brain Mapping	en
dc.subject.other	Child	en
dc.subject.other	Dose-Response Relationship, Radiation	en
dc.subject.other	Dyslexia	en
dc.subject.other	Electroencephalography	en
dc.subject.other	Evoked Potentials	en
dc.subject.other	Female	en
dc.subject.other	Gyrus Cinguli	en
dc.subject.other	Humans	en
dc.subject.other	Magnetic Resonance Imaging	en
dc.subject.other	Male	en
dc.subject.other	Psychomotor Performance	en
dc.subject.other	Reaction Time	en
dc.subject.other	Signal Processing, Computer-Assisted	en
dc.title	Evidence of a posterior cingulate involvement (Brodmann area 31) in dyslexia: A study based on source localization algorithm of event-related potentials	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.pnpbp.2007.11.022	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.pnpbp.2007.11.022	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	The study investigates the differences regarding the position of intracranial generators of P50 component of ERPs in 38 dyslexic children aged 11.47 +/- 2.12 years compared with their 19 healthy siblings aged 12.21 +/- 2.25. The dipoles were extracted by solving the inverse electromagnetic problem according to the recursively applied and projected multiple signal classification (RAP-MUSIC) algorithm approach. For improved localization of the main dipole the solutions were optimized using genetic algorithms. The statistical analysis revealed differences regarding the position of intracranial generators of low frequency of P50. Particularly, dyslexics showed main activity being located at posterior cingulate cortex (Brodmann's area 31) while controls exhibited main activity being located at retrosplenial cortex (Brodmann's area 31). These results may indicate a role for the posterior cingulate cortex in the pre-attentive processing operation of dyslexia beyond of its traditional function in terms of spatial attention and motor intention. (C) 2007 Elsevier Inc. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Progress in Neuro-Psychopharmacology and Biological Psychiatry	en
dc.identifier.doi	10.1016/j.pnpbp.2007.11.022	en
dc.identifier.isi	ISI:000254690300018	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	733	en
dc.identifier.epage	738	en