FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues

Conti, C; Ferraris, P; Giorgini, E; Rubini, C; Sabbatini, S; Tosi, G; Anastassopoulou, J; Arapantoni, P; Boukaki, E; Konstadoudakis, S; Theophanides, T; Valavanis, C

dc.contributor.author	Conti, C	en
dc.contributor.author	Ferraris, P	en
dc.contributor.author	Giorgini, E	en
dc.contributor.author	Rubini, C	en
dc.contributor.author	Sabbatini, S	en
dc.contributor.author	Tosi, G	en
dc.contributor.author	Anastassopoulou, J	en
dc.contributor.author	Arapantoni, P	en
dc.contributor.author	Boukaki, E	en
dc.contributor.author	Konstadoudakis, S	en
dc.contributor.author	Theophanides, T	en
dc.contributor.author	Valavanis, C	en
dc.date.accessioned	2014-03-01T01:28:29Z
dc.date.available	2014-03-01T01:28:29Z
dc.date.issued	2008	en
dc.identifier.issn	0022-2860	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18852
dc.subject	Colon adenocarcinoma	en
dc.subject	FT-IR microspectroscopy	en
dc.subject	Imaging	en
dc.subject	NIR spectroscopy	en
dc.subject.classification	Chemistry, Physical	en
dc.subject.other	Fourier transform infrared spectroscopy	en
dc.subject.other	Histology	en
dc.subject.other	Near infrared spectroscopy	en
dc.subject.other	Pathology	en
dc.subject.other	Statistical methods	en
dc.subject.other	Tissue	en
dc.subject.other	Colon adenocarcinoma	en
dc.subject.other	Histopathological analysis	en
dc.subject.other	Mid infrared region	en
dc.subject.other	Pathological tissues	en
dc.subject.other	Medical imaging	en
dc.title	FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.molstruc.2007.08.040	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.molstruc.2007.08.040	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	FT-IR microimaging was performed on colon tissues with the aim to characterize spectral 'markers' to distinguish healthy from pathological tissues. Evidences of spectral peculiarities were mainly found in the finger print region even in the presence of a low grade adenocarcinoma. The occurrence of inflammation and necrotic states can also be demonstrated. Through statistical analysis as well as custom map procedures it was possible to reconstruct the topological distribution of different biochemical states and to verify results from the histopathological analysis. Preliminary results from FT-NIR analysis are in substantial agreement with those in the mid infrared region. (C) 2007 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Molecular Structure	en
dc.identifier.doi	10.1016/j.molstruc.2007.08.040	en
dc.identifier.isi	ISI:000257094000005	en
dc.identifier.volume	881	en
dc.identifier.issue	1-3	en
dc.identifier.spage	46	en
dc.identifier.epage	51	en