Herpes simplex virus seroprevalence among children, adolescents and adults in Greece

Papadogeorgakis, H; Caroni, C; Katsambas, A; Pimenta, JM; Avdeliodi, C; Kotrotsou, T; Frangoulis, E; Smith, JS

dc.contributor.author	Papadogeorgakis, H	en
dc.contributor.author	Caroni, C	en
dc.contributor.author	Katsambas, A	en
dc.contributor.author	Pimenta, JM	en
dc.contributor.author	Avdeliodi, C	en
dc.contributor.author	Kotrotsou, T	en
dc.contributor.author	Frangoulis, E	en
dc.contributor.author	Smith, JS	en
dc.date.accessioned	2014-03-01T01:28:34Z
dc.date.available	2014-03-01T01:28:34Z
dc.date.issued	2008	en
dc.identifier.issn	0956-4624	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18876
dc.subject	Greece	en
dc.subject	Herpes simplex virus	en
dc.subject	Risk factors	en
dc.subject	Seroprevalence	en
dc.subject.classification	Immunology	en
dc.subject.classification	Infectious Diseases	en
dc.subject.other	adolescent	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	child	en
dc.subject.other	diagnostic kit	en
dc.subject.other	education	en
dc.subject.other	female	en
dc.subject.other	Greece	en
dc.subject.other	herpes simplex	en
dc.subject.other	Herpes simplex virus 1	en
dc.subject.other	Herpes simplex virus 2	en
dc.subject.other	human	en
dc.subject.other	infant	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	newborn	en
dc.subject.other	priority journal	en
dc.subject.other	risk factor	en
dc.subject.other	seroprevalence	en
dc.subject.other	sexual behavior	en
dc.subject.other	socioeconomics	en
dc.subject.other	Adolescent	en
dc.subject.other	Adult	en
dc.subject.other	Child	en
dc.subject.other	Child, Preschool	en
dc.subject.other	Enzyme-Linked Immunosorbent Assay	en
dc.subject.other	Female	en
dc.subject.other	Greece	en
dc.subject.other	Herpes Simplex	en
dc.subject.other	Humans	en
dc.subject.other	Infant	en
dc.subject.other	Infant, Newborn	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Seroepidemiologic Studies	en
dc.subject.other	Simplexvirus	en
dc.title	Herpes simplex virus seroprevalence among children, adolescents and adults in Greece	en
heal.type	journalArticle	en
heal.identifier.primary	10.1258/ijsa.2007.007142	en
heal.identifier.secondary	http://dx.doi.org/10.1258/ijsa.2007.007142	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	The aim was to study the type-specific seroprevalence of Herpes simplex virus (HSV)-1 and HSV-2 infections and the associated risk factors in children, adolescents and adults in Greece. A total of 1867 serum samples from children, adolescents and adults of both genders aged from 0 to 60 years were collected from three large hospital -referral centres in Athens. All sera were tested for type-specific antibodies to HSV-1 and HSV-2 using HerpeSelect IgG ELISA tests (Focus Diagnostics Cypress, Cal, USA). Overall age-adjusted seroprevalence of HSV-1 and HSV-2 was 72.0% and 10.2%, respectively. HSV-1 seropositivity was low in children up to nine years of age, increased sharply in adolescence, and was higher in females than males in each group surveyed. HSV-2 seropositivity was low (0.8%) below 20 years of age and increased to a maximum prevalence of 18.7% in men and 22.7% in women. Multivariate risk factor analyses indicated that HSV-1 seropositivity was associated with socioeconomic indicators (e.g. lower educational level, residency outside greater Athens), whereas HSV-2 was associated with sexual behavioural factors (e.g. being divorced, greater number of lifetime sexual partners). HSV-2 risk factor profiles were similar in women and in men. This first large seroprevalence study in Greece showed a high age-standardized HSV-1 seropositivity after adolescence and a relatively low age-standardized HSV-2 seroprevalence from birth to 60 years of age. Dual seropositivity to HSV-1 and HSV-2 was low (0.6%) in females under 20 years of age, suggesting that the potential use of an HSV-2 prophylactic vaccine in adolescents could reduce the spread of HSV-2 infection.	en
heal.publisher	ROYAL SOC MEDICINE PRESS LTD	en
heal.journalName	International Journal of STD and AIDS	en
dc.identifier.doi	10.1258/ijsa.2007.007142	en
dc.identifier.isi	ISI:000255834200013	en
dc.identifier.volume	19	en
dc.identifier.issue	4	en
dc.identifier.spage	272	en
dc.identifier.epage	278	en