In vitro fluorescence measurements and Monte Carlo simulation of laser irradiation propagation in porcine skin tissue

Drakaki, E; Makropoulou, M; Serafetinides, AA

dc.contributor.author	Drakaki, E	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Serafetinides, AA	en
dc.date.accessioned	2014-03-01T01:28:40Z
dc.date.available	2014-03-01T01:28:40Z
dc.date.issued	2008	en
dc.identifier.issn	0268-8921	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18910
dc.subject	Fat	en
dc.subject	Haemoglobin	en
dc.subject	Laser-induced fluorescence	en
dc.subject	Melanin	en
dc.subject	Monte Carlo simulation	en
dc.subject	Skin	en
dc.subject	UV radiation	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Surgery	en
dc.subject.other	fat	en
dc.subject.other	hemoglobin	en
dc.subject.other	melanin	en
dc.subject.other	absorption	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	concentration response	en
dc.subject.other	controlled study	en
dc.subject.other	fluorescence	en
dc.subject.other	in vitro study	en
dc.subject.other	laser	en
dc.subject.other	measurement	en
dc.subject.other	Monte Carlo method	en
dc.subject.other	non invasive measurement	en
dc.subject.other	nonhuman	en
dc.subject.other	optics	en
dc.subject.other	priority journal	en
dc.subject.other	quantitative analysis	en
dc.subject.other	signal detection	en
dc.subject.other	skin culture	en
dc.subject.other	standard	en
dc.subject.other	swine	en
dc.subject.other	ultraviolet radiation	en
dc.subject.other	Animals	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Lasers	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Skin	en
dc.subject.other	Skin Physiological Phenomena	en
dc.subject.other	Spectrometry, Fluorescence	en
dc.subject.other	Swine	en
dc.title	In vitro fluorescence measurements and Monte Carlo simulation of laser irradiation propagation in porcine skin tissue	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s10103-007-0478-2	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s10103-007-0478-2	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	In dermatology, the in vivo spectral fluorescence measurements of human skin can serve as a valuable supplement to standard non-invasive techniques for diagnosing various skin diseases. However, quantitative analysis of the fluorescence spectra is complicated by the fact that skin is a complex multi-layered and inhomogeneous organ, with varied optical properties and biophysical characteristics. In this work, we recorded, in vitro, the laser-induced fluorescence emission signals of healthy porcine skin, one of the animals, which is considered as one of the most common models for investigations related to medical diagnostics of human cutaneous tissues. Differences were observed in the form and intensity of the fluorescence signal of the porcine skin, which can be attributed to the different concentrations of the native fluorophores and the variable physical and biological conditions of the skin tissue. As the light transport in the tissue target is directly influencing the absorption and the fluorescence emission signals, we performed Monte Carlo simulation of the light distribution in a five-layer model of human skin tissue, with a pulsed ultraviolet laser beam. © 2007 Springer-Verlag London Limited.	en
heal.publisher	SPRINGER LONDON LTD	en
heal.journalName	Lasers in Medical Science	en
dc.identifier.doi	10.1007/s10103-007-0478-2	en
dc.identifier.isi	ISI:000256912200007	en
dc.identifier.volume	23	en
dc.identifier.issue	3	en
dc.identifier.spage	267	en
dc.identifier.epage	276	en