Numerical modelling of simulated blood flow in idealized composite arterial coronary grafts: Transient flow

Politis, AK; Stavropoulos, GP; Christolis, MN; Panagopoulos, PG; Vlachos, NS; Markatos, NC

dc.contributor.author	Politis, AK	en
dc.contributor.author	Stavropoulos, GP	en
dc.contributor.author	Christolis, MN	en
dc.contributor.author	Panagopoulos, PG	en
dc.contributor.author	Vlachos, NS	en
dc.contributor.author	Markatos, NC	en
dc.date.accessioned	2014-03-01T01:28:53Z
dc.date.available	2014-03-01T01:28:53Z
dc.date.issued	2008	en
dc.identifier.issn	0021-9290	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19017
dc.subject	CFD	en
dc.subject	Composite arterial coronary grafts	en
dc.subject	Coronary artery disease	en
dc.subject	Pulsating flow	en
dc.subject.classification	Biophysics	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.other	Computational fluid dynamics	en
dc.subject.other	Computer simulation	en
dc.subject.other	Diseases	en
dc.subject.other	Pathology	en
dc.subject.other	Pulsatile flow	en
dc.subject.other	Waveform analysis	en
dc.subject.other	Blood flow dynamics	en
dc.subject.other	Composite arterial coronary grafts	en
dc.subject.other	Coronary artery diseases	en
dc.subject.other	Transient flow	en
dc.subject.other	Blood	en
dc.subject.other	artery constriction	en
dc.subject.other	artery occlusion	en
dc.subject.other	article	en
dc.subject.other	blood flow	en
dc.subject.other	blood flow velocity	en
dc.subject.other	computational fluid dynamics	en
dc.subject.other	coronary artery blood flow	en
dc.subject.other	coronary artery bypass graft	en
dc.subject.other	coronary artery disease	en
dc.subject.other	geometry	en
dc.subject.other	heart hemodynamics	en
dc.subject.other	mathematical analysis	en
dc.subject.other	mathematical model	en
dc.subject.other	molecular dynamics	en
dc.subject.other	oscillation	en
dc.subject.other	priority journal	en
dc.subject.other	pulsatile flow	en
dc.subject.other	restenosis	en
dc.subject.other	revascularization	en
dc.subject.other	shear stress	en
dc.subject.other	waveform	en
dc.subject.other	Algorithms	en
dc.subject.other	Blood Flow Velocity	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Coronary Artery Bypass	en
dc.subject.other	Coronary Circulation	en
dc.subject.other	Coronary Restenosis	en
dc.subject.other	Coronary Stenosis	en
dc.subject.other	Diastole	en
dc.subject.other	Hemorheology	en
dc.subject.other	Humans	en
dc.subject.other	Models, Biological	en
dc.subject.other	Pulsatile Flow	en
dc.subject.other	Stress, Mechanical	en
dc.subject.other	Systole	en
dc.title	Numerical modelling of simulated blood flow in idealized composite arterial coronary grafts: Transient flow	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.jbiomech.2007.08.007	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.jbiomech.2007.08.007	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	In composite arterial coronary grafts (CACGs), transport phenomena and geometry may considerably alter blood flow dynamics. CACGs aim at revascularizing pathological arteries according to the human anatomy. However, the exact mechanisms causing the failure of coronary bypass grafting are not yet well elucidated. In the present study, computational fluid dynamics (CFD) techniques are applied for the simulation of multi-branched CACGs under physiologically realistic inflow waveforms. The numerical solution is obtained by a finite-volume method formulated in non-orthogonal, curvilinear coordinates and a multi-grid approach. The geometrical models, consisting of idealized and rigid vessels, include the typical T- and a rather new Pi-graft configuration. The stenotic effect is also investigated by comparing computational results for three different degrees of area constriction, namely 25%, 50% and 75%, as well as the case without stenosis. Different grafting distances and various inflow rate ratios are imposed, to give an insight into haemodynamical alterations of CACGs and to study the process of restenosis. The results focus on the interaction between the grafts and coronary flows in terms of spatial and temporal variations of velocity and wall shear stress (WSS) distribution. Prominent variations among the different geometries, concerning the velocity profiles and secondary flow motion, are shown. Moreover, the residual flow emerging from different degrees of area constriction shows that low and oscillating shear stresses may arise for even moderate stenotic fields. (c) 2007 Elsevier Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI LTD	en
heal.journalName	Journal of Biomechanics	en
dc.identifier.doi	10.1016/j.jbiomech.2007.08.007	en
dc.identifier.isi	ISI:000253062100004	en
dc.identifier.volume	41	en
dc.identifier.issue	1	en
dc.identifier.spage	25	en
dc.identifier.epage	39	en