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Numerical modelling of simulated blood flow in idealized composite arterial coronary grafts: Transient flow

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dc.contributor.author Politis, AK en
dc.contributor.author Stavropoulos, GP en
dc.contributor.author Christolis, MN en
dc.contributor.author Panagopoulos, PG en
dc.contributor.author Vlachos, NS en
dc.contributor.author Markatos, NC en
dc.date.accessioned 2014-03-01T01:28:53Z
dc.date.available 2014-03-01T01:28:53Z
dc.date.issued 2008 en
dc.identifier.issn 0021-9290 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/19017
dc.subject CFD en
dc.subject Composite arterial coronary grafts en
dc.subject Coronary artery disease en
dc.subject Pulsating flow en
dc.subject.classification Biophysics en
dc.subject.classification Engineering, Biomedical en
dc.subject.other Computational fluid dynamics en
dc.subject.other Computer simulation en
dc.subject.other Diseases en
dc.subject.other Pathology en
dc.subject.other Pulsatile flow en
dc.subject.other Waveform analysis en
dc.subject.other Blood flow dynamics en
dc.subject.other Composite arterial coronary grafts en
dc.subject.other Coronary artery diseases en
dc.subject.other Transient flow en
dc.subject.other Blood en
dc.subject.other artery constriction en
dc.subject.other artery occlusion en
dc.subject.other article en
dc.subject.other blood flow en
dc.subject.other blood flow velocity en
dc.subject.other computational fluid dynamics en
dc.subject.other coronary artery blood flow en
dc.subject.other coronary artery bypass graft en
dc.subject.other coronary artery disease en
dc.subject.other geometry en
dc.subject.other heart hemodynamics en
dc.subject.other mathematical analysis en
dc.subject.other mathematical model en
dc.subject.other molecular dynamics en
dc.subject.other oscillation en
dc.subject.other priority journal en
dc.subject.other pulsatile flow en
dc.subject.other restenosis en
dc.subject.other revascularization en
dc.subject.other shear stress en
dc.subject.other waveform en
dc.subject.other Algorithms en
dc.subject.other Blood Flow Velocity en
dc.subject.other Computer Simulation en
dc.subject.other Coronary Artery Bypass en
dc.subject.other Coronary Circulation en
dc.subject.other Coronary Restenosis en
dc.subject.other Coronary Stenosis en
dc.subject.other Diastole en
dc.subject.other Hemorheology en
dc.subject.other Humans en
dc.subject.other Models, Biological en
dc.subject.other Pulsatile Flow en
dc.subject.other Stress, Mechanical en
dc.subject.other Systole en
dc.title Numerical modelling of simulated blood flow in idealized composite arterial coronary grafts: Transient flow en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.jbiomech.2007.08.007 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.jbiomech.2007.08.007 en
heal.language English en
heal.publicationDate 2008 en
heal.abstract In composite arterial coronary grafts (CACGs), transport phenomena and geometry may considerably alter blood flow dynamics. CACGs aim at revascularizing pathological arteries according to the human anatomy. However, the exact mechanisms causing the failure of coronary bypass grafting are not yet well elucidated. In the present study, computational fluid dynamics (CFD) techniques are applied for the simulation of multi-branched CACGs under physiologically realistic inflow waveforms. The numerical solution is obtained by a finite-volume method formulated in non-orthogonal, curvilinear coordinates and a multi-grid approach. The geometrical models, consisting of idealized and rigid vessels, include the typical T- and a rather new Pi-graft configuration. The stenotic effect is also investigated by comparing computational results for three different degrees of area constriction, namely 25%, 50% and 75%, as well as the case without stenosis. Different grafting distances and various inflow rate ratios are imposed, to give an insight into haemodynamical alterations of CACGs and to study the process of restenosis. The results focus on the interaction between the grafts and coronary flows in terms of spatial and temporal variations of velocity and wall shear stress (WSS) distribution. Prominent variations among the different geometries, concerning the velocity profiles and secondary flow motion, are shown. Moreover, the residual flow emerging from different degrees of area constriction shows that low and oscillating shear stresses may arise for even moderate stenotic fields. (c) 2007 Elsevier Ltd. All rights reserved. en
heal.publisher ELSEVIER SCI LTD en
heal.journalName Journal of Biomechanics en
dc.identifier.doi 10.1016/j.jbiomech.2007.08.007 en
dc.identifier.isi ISI:000253062100004 en
dc.identifier.volume 41 en
dc.identifier.issue 1 en
dc.identifier.spage 25 en
dc.identifier.epage 39 en


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