Sustained release of guaifenesin and ipriflavone from biodegradable coatings

Tarantili, PA; Koumoulos, H

dc.contributor.author	Tarantili, PA	en
dc.contributor.author	Koumoulos, H	en
dc.date.accessioned	2014-03-01T01:29:16Z
dc.date.available	2014-03-01T01:29:16Z
dc.date.issued	2008	en
dc.identifier.issn	0014-3057	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19196
dc.subject	Biodegradable polymers	en
dc.subject	Coatings	en
dc.subject	Poly(lactic acid)	en
dc.subject	Sustained drug release	en
dc.subject.classification	Polymer Science	en
dc.subject.other	Biodegradation	en
dc.subject.other	Casting	en
dc.subject.other	Coatings	en
dc.subject.other	Drug delivery	en
dc.subject.other	Implants (surgical)	en
dc.subject.other	Lactic acid	en
dc.subject.other	Solvent extraction	en
dc.subject.other	Stainless steel	en
dc.subject.other	Biodegradable plastics	en
dc.subject.other	Guaifenesin	en
dc.subject.other	Polylactic acid	en
dc.subject.other	Sustained drug release	en
dc.subject.other	Biodegradable polymers	en
dc.title	Sustained release of guaifenesin and ipriflavone from biodegradable coatings	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.eurpolymj.2007.11.014	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.eurpolymj.2007.11.014	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Biodegradable plastics are an interesting class of drug carriers for controlled release, as they can decompose to nontoxic, readily bioresorbable products and are advantageous over conventional biomaterials because they do not require surgical retrieval from the body after completion of treatment. In this work, films of poly(D,L-lactic acid) (D,L-PLA) were deposited by the solvent casting technique, onto the surfaces of stainless steel plates and their biodegradation was studied after immersion in buffer solutions. The release of two model drugs, i.e. guaifenesin and ipriflavone, from the above D,L-PLA systems loaded with these compounds at various concentrations, was also studied. The experimental results showed that for low drug concentrations, the release of guaifenesin is controlled by the biodegradation rate of PLA, whereas for high concentrations the burst effect becomes the dominant release mechanism. The rate of release is faster at low pH values probably due to an acceleration of PLA biodegradation, whereas there are no chemical interactions between drug and polymer, that could essentially influence the release rate of the drug or the biodegradation of the polymer. On the other hand, high guaifenesin concentrations produce increased porosity in the PLA matrix and seem to accelerate its biodegradation and further the drug release rate. Finally, the release of ipriflavone in a mixture of 2-propanol/water is clearly a two stage process and, again, the burst effect seems to control the delivery process at high drug concentration. In conclusion, the present study shows that similar results to those obtained With D,L-PLA tablets loaded with model drugs can be obtained with thin coatings of the same systems. This might be of interest for transfer of the existing knowledge to the design of biomedical implants, treated with coatings Of D,L-PLA containing reactive compounds. (c) 2007 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	European Polymer Journal	en
dc.identifier.doi	10.1016/j.eurpolymj.2007.11.014	en
dc.identifier.isi	ISI:000254116500018	en
dc.identifier.volume	44	en
dc.identifier.issue	2	en
dc.identifier.spage	444	en
dc.identifier.epage	452	en