Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: Pharmacokinetics, tumor response and cosmetic outcomes

Kyriazi, M; Alexandratou, E; Yova, D; Rallis, M; Trebst, T

dc.contributor.author	Kyriazi, M	en
dc.contributor.author	Alexandratou, E	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Rallis, M	en
dc.contributor.author	Trebst, T	en
dc.date.accessioned	2014-03-01T01:29:22Z
dc.date.available	2014-03-01T01:29:22Z
dc.date.issued	2008	en
dc.identifier.issn	0905-4383	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19248
dc.subject	Aluminum phthalocyanine chloride	en
dc.subject	Non-melanoma skin carcinomas	en
dc.subject	Photodynamic therapy	en
dc.subject	Topical administration	en
dc.subject.classification	Dermatology	en
dc.subject.other	phthalocyanine aluminum	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	cancer growth	en
dc.subject.other	cancer inhibition	en
dc.subject.other	cancer regression	en
dc.subject.other	controlled study	en
dc.subject.other	diode laser	en
dc.subject.other	drug absorption	en
dc.subject.other	drug efficacy	en
dc.subject.other	drug penetration	en
dc.subject.other	drug response	en
dc.subject.other	drug tissue level	en
dc.subject.other	drug tumor level	en
dc.subject.other	esthetics	en
dc.subject.other	female	en
dc.subject.other	low level laser therapy	en
dc.subject.other	male	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	photodynamic therapy	en
dc.subject.other	priority journal	en
dc.subject.other	skin carcinoma	en
dc.subject.other	treatment outcome	en
dc.subject.other	Administration, Cutaneous	en
dc.subject.other	Animals	en
dc.subject.other	Carcinoma, Basal Cell	en
dc.subject.other	Female	en
dc.subject.other	Indoles	en
dc.subject.other	Male	en
dc.subject.other	Mice	en
dc.subject.other	Mice, Inbred Strains	en
dc.subject.other	Neoplasm Recurrence, Local	en
dc.subject.other	Neoplasm Transplantation	en
dc.subject.other	Organometallic Compounds	en
dc.subject.other	Photochemotherapy	en
dc.subject.other	Photosensitizing Agents	en
dc.subject.other	Skin Neoplasms	en
dc.title	Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: Pharmacokinetics, tumor response and cosmetic outcomes	en
heal.type	journalArticle	en
heal.identifier.primary	10.1111/j.1600-0781.2008.00345.x	en
heal.identifier.secondary	http://dx.doi.org/10.1111/j.1600-0781.2008.00345.x	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Background/purpose: Topical photodynamic therapy (PDT) is potentially useful for the treatment of non-melanoma skin cancer and other skin diseases. We investigated the therapeutic effects of PDT using topical application of aluminum phthalocyanine chloride (AlClPc) and a diode laser emitting at 670nm in murine non-melanoma skin carcinomas. Methods: AlClPc solution (0.7% w/v) was applied to tumors in mice for 1-6h. The penetration depth and the optimum drug-light interval were assessed using pharmacokinetic studies. Then, PDT was performed on a murine model of non-melanoma skin cancer using seven different combinations of therapeutic parameters (fluence rate and energy dose). Results: Pharmacokinetic studies revealed that AlClPc was absorbed 40 times more and penetrated 19 times deeper in tumors than normal skin. PDT using AlClPc (0.7% w/v) and a diode laser (75mW/cm 2, 150J/cm 2) resulted in complete tumor remission in 60% of the mice, excellent cosmetic outcomes and growth retardation of tumors with partial remission. Conclusions: The results indicate that AlClPc-PDT is an effective treatment for non-melanoma skin carcinomas in experimental mouse models. © Journal compilation © 2008 Blackwell Munksgaard.	en
heal.publisher	BLACKWELL PUBLISHING	en
heal.journalName	Photodermatology Photoimmunology and Photomedicine	en
dc.identifier.doi	10.1111/j.1600-0781.2008.00345.x	en
dc.identifier.isi	ISI:000254054600007	en
dc.identifier.volume	24	en
dc.identifier.issue	2	en
dc.identifier.spage	87	en
dc.identifier.epage	94	en