A radionuclide dosimetry toolkit based on material-specific Monte Carlo dose kernels

Loudos, G; Tsougos, I; Boukis, S; Karakatsanis, N; Georgoulias, P; Theodorou, K; Nikita, K; Kappas, C

dc.contributor.author	Loudos, G	en
dc.contributor.author	Tsougos, I	en
dc.contributor.author	Boukis, S	en
dc.contributor.author	Karakatsanis, N	en
dc.contributor.author	Georgoulias, P	en
dc.contributor.author	Theodorou, K	en
dc.contributor.author	Nikita, K	en
dc.contributor.author	Kappas, C	en
dc.date.accessioned	2014-03-01T01:29:36Z
dc.date.available	2014-03-01T01:29:36Z
dc.date.issued	2009	en
dc.identifier.issn	0143-3636	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19328
dc.subject	Dose kernel	en
dc.subject	Dosimetry	en
dc.subject	Geant4 Application for Tomographic Emission	en
dc.subject	Monte Carlo simulations	en
dc.subject	Radionuclide therapy	en
dc.subject	Treatment planning	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	samarium 153	en
dc.subject.other	yttrium 90	en
dc.subject.other	accuracy	en
dc.subject.other	article	en
dc.subject.other	calculation	en
dc.subject.other	computer assisted tomography	en
dc.subject.other	computer program	en
dc.subject.other	data extraction	en
dc.subject.other	dose calculation	en
dc.subject.other	dosimetry	en
dc.subject.other	emission tomography	en
dc.subject.other	information processing	en
dc.subject.other	kernel method	en
dc.subject.other	materials	en
dc.subject.other	Monte Carlo method	en
dc.subject.other	nuclear magnetic resonance imaging	en
dc.subject.other	quantitative analysis	en
dc.subject.other	radiation dose	en
dc.subject.other	simulation	en
dc.subject.other	standardization	en
dc.subject.other	treatment planning	en
dc.subject.other	Bone and Bones	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Positron-Emission Tomography	en
dc.subject.other	Radiometry	en
dc.subject.other	Radiotherapy Dosage	en
dc.subject.other	Software	en
dc.subject.other	Tomography, X-Ray Computed	en
dc.subject.other	User-Computer Interface	en
dc.subject.other	Water	en
dc.title	A radionuclide dosimetry toolkit based on material-specific Monte Carlo dose kernels	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/MNM.0b013e3283299a11	en
heal.identifier.secondary	http://dx.doi.org/10.1097/MNM.0b013e3283299a11	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Objective We sought to develop a user-friendly dosimetry toolkit that should aid the improvement of the quality of radionuclide therapy, which is critically dependent on patient-specific planning of each treatment. Methods In this work, we present a new toolkit suitable for indicative radionuclide dose calculation. The software is built using open source tools and it uses dose kernels calculated using the Geant4 Application for Tomographic Emission simulation toolkit. In addition, a method that uses kernel data to extract a material-specific dose absorption factor is described and a proof of concept is given. In this work, time dependency and organ sensitivity are not modeled. Results The developed software utilizes Monte Carlo calculated dose kernels and proposes a fast dose calculation method. Using computed tomography or magnetic resonance imaging it can provide a more accurate and personalized indicative dose map. Conclusion Dosimetry based on quantitative three-dimensional data is more accurate and allows a more individualized approach in patient therapy. Moreover, the use of this toolkit with the standardization for data collection and processing will increase the accuracy as well as the compatibility of radiation dose. Nucl Med Commun 30:504-512 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	Nuclear Medicine Communications	en
dc.identifier.doi	10.1097/MNM.0b013e3283299a11	en
dc.identifier.isi	ISI:000267044300005	en
dc.identifier.volume	30	en
dc.identifier.issue	7	en
dc.identifier.spage	504	en
dc.identifier.epage	512	en