Abnormal auditory ERP N100 in children with dyslexia: Comparison with their control siblings

Papageorgiou, C; Giannakakis, GA; Nikita, KS; Anagnostopoulos, D; Papadimitriou, GN; Rabavilas, A

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Giannakakis, GA	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Anagnostopoulos, D	en
dc.contributor.author	Papadimitriou, GN	en
dc.contributor.author	Rabavilas, A	en
dc.date.accessioned	2014-03-01T01:29:46Z
dc.date.available	2014-03-01T01:29:46Z
dc.date.issued	2009	en
dc.identifier.issn	1744-9081	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19340
dc.subject	event-related potential erp	en
dc.subject	High Frequency	en
dc.subject	International Classification of Diseases	en
dc.subject	Memory Performance	en
dc.subject	Working Memory	en
dc.subject	and Forward	en
dc.subject	Control Group	en
dc.subject	Digit Span	en
dc.subject	Low Frequency	en
dc.subject.classification	Behavioral Sciences	en
dc.subject.classification	Neurosciences	en
dc.subject.other	adolescent	en
dc.subject.other	article	en
dc.subject.other	attention	en
dc.subject.other	auditory stimulation	en
dc.subject.other	child	en
dc.subject.other	clinical article	en
dc.subject.other	comparative study	en
dc.subject.other	controlled study	en
dc.subject.other	dyslexia	en
dc.subject.other	evoked auditory response	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	hypothesis	en
dc.subject.other	international classification of diseases	en
dc.subject.other	male	en
dc.subject.other	mental performance	en
dc.subject.other	priority journal	en
dc.subject.other	school child	en
dc.subject.other	sibling	en
dc.subject.other	working memory	en
dc.title	Abnormal auditory ERP N100 in children with dyslexia: Comparison with their control siblings	en
heal.type	journalArticle	en
heal.identifier.primary	10.1186/1744-9081-5-26	en
heal.identifier.secondary	http://dx.doi.org/10.1186/1744-9081-5-26	en
heal.identifier.secondary	26	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Background: Recent research has implicated deficits of the working memory (WM) and attention in dyslexia. The N100 component of event-related potentials (ERP) is thought to reflect attention and working memory operation. However, previous studies showed controversial results concerning the N100 in dyslexia. Variability in this issue may be the result of inappropriate match up of the control sample, which is usually based exclusively on age and gender. Methods: In order to address this question the present study aimed at investigating the auditory N100 component elicited during a WM test in 38 dyslexic children in comparison to those of 19 unaffected sibling controls. Both groups met the criteria of the International Classification of Diseases (ICD-10). ERP were evoked by two stimuli, a low (500 Hz) and a high (3000 Hz) frequency tone indicating forward and reverse digit span respectively. Results: As compared to their sibling controls, dyslexic children exhibited significantly reduced N100 amplitudes induced by both reverse and forward digit span at Fp1, F3, Fp2, Fz, C4, Cz and F4 and at Fp1, F3, C5, C3, Fz, F4, C6, P4 and Fp2 leads respectively. Memory performance of the dyslexics group was not significantly lower than that of the controls. However, enhanced memory performance in the control group is associated with increased N100 amplitude induced by high frequency stimuli at the C5, C3, C6 and P4 leads and increased N100 amplitude induced by low frequency stimuli at the P4 lead. Conclusion: The present findings are in support of the notion of weakened capture of auditory attention in dyslexia, allowing for a possible impairment in the dynamics that link attention with short memory, suggested by the anchoring-deficit hypothesis. © 2009 Papageorgiou et al; licensee BioMed Central Ltd.	en
heal.publisher	BIOMED CENTRAL LTD	en
heal.journalName	Behavioral and Brain Functions	en
dc.identifier.doi	10.1186/1744-9081-5-26	en
dc.identifier.isi	ISI:000268416200001	en
dc.identifier.volume	5	en