Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging

Pattinson, KTS; Mitsis, GD; Harvey, AK; Jbabdi, S; Dirckx, S; Mayhew, SD; Rogers, R; Tracey, I; Wise, RG

dc.contributor.author	Pattinson, KTS	en
dc.contributor.author	Mitsis, GD	en
dc.contributor.author	Harvey, AK	en
dc.contributor.author	Jbabdi, S	en
dc.contributor.author	Dirckx, S	en
dc.contributor.author	Mayhew, SD	en
dc.contributor.author	Rogers, R	en
dc.contributor.author	Tracey, I	en
dc.contributor.author	Wise, RG	en
dc.date.accessioned	2014-03-01T01:30:09Z
dc.date.available	2014-03-01T01:30:09Z
dc.date.issued	2009	en
dc.identifier.issn	1053-8119	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19486
dc.subject.classification	Neurosciences	en
dc.subject.classification	Neuroimaging	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	carbon dioxide	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	brain cortex	en
dc.subject.other	brain stem	en
dc.subject.other	diffusion weighted imaging	en
dc.subject.other	female	en
dc.subject.other	functional magnetic resonance imaging	en
dc.subject.other	human	en
dc.subject.other	human experiment	en
dc.subject.other	image analysis	en
dc.subject.other	male	en
dc.subject.other	medulla oblongata	en
dc.subject.other	normal human	en
dc.subject.other	pons	en
dc.subject.other	priority journal	en
dc.subject.other	putamen	en
dc.subject.other	respiration center	en
dc.subject.other	respiration control	en
dc.subject.other	thalamus	en
dc.subject.other	Adult	en
dc.subject.other	Brain Stem	en
dc.subject.other	Carbon Dioxide	en
dc.subject.other	Feedback	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Magnetic Resonance Imaging	en
dc.subject.other	Male	en
dc.subject.other	Neural Pathways	en
dc.subject.other	Oxygen Consumption	en
dc.subject.other	Respiratory Mechanics	en
dc.subject.other	Thalamus	en
dc.title	Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.neuroimage.2008.09.007	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.neuroimage.2008.09.007	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	This study combined functional and structural magnetic resonance imaging techniques, optimized for the human brainstem, to investigate activity in brainstem respiratory control centres in a group of 12 healthy human volunteers. We stimulated respiration with carbon dioxide (CO2), and utilized novel methodology to separate its vascular from its neuronal effects upon the blood oxygen level dependent (BOLD) signal. In the brainstem we observed activity in the dorsal rostral pons (representing the Kolliker-Fuse/parabrachial (KF/PB) nuclei and locus coeruleus), the inferior ventral pons and the dorsal and lateral medulla. These areas of activation correspond to respiratory nuclei identified in recent rodent studies. Our results also reveal functional participation of the anteroventral (AV), ventral posterolateral (VPL) ventrolateral thalamic nuclei, and the posterior putamen in the response to CO2 stimulation, suggesting that these centres may play a role in gating respiratory information to the cortex. As the functional imaging plane was limited to the brainstem and adjacent subcortical areas, we employed diffusion tractography to further investigate cortical connectivity of the thalamic activations. This revealed distinct connectivity profiles of these thalamic activations suggesting subdivision of the thalamus with regards to respiratory control. From these results we speculate that the thalamus plays an important role in integrating respiratory signals to and from the brainstem respiratory centres. (C) 2008 Elsevier Inc. All rights reserved.	en
heal.publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE	en
heal.journalName	NeuroImage	en
dc.identifier.doi	10.1016/j.neuroimage.2008.09.007	en
dc.identifier.isi	ISI:000262301100001	en
dc.identifier.volume	44	en
dc.identifier.issue	2	en
dc.identifier.spage	295	en
dc.identifier.epage	305	en