Effect of initiation-inhibition and handedness on the patterns of the P50 event-related potential component: a low resolution electromagnetic tomography study

Beratis, IN; Rabavilas, A; Nanou, ED; Hountala, C; Maganioti, AE; Capsalis, CN; Papadimitriou, GN; Papageorgiou, C

dc.contributor.author	Beratis, IN	en
dc.contributor.author	Rabavilas, A	en
dc.contributor.author	Nanou, ED	en
dc.contributor.author	Hountala, C	en
dc.contributor.author	Maganioti, AE	en
dc.contributor.author	Capsalis, CN	en
dc.contributor.author	Papadimitriou, GN	en
dc.contributor.author	Papageorgiou, C	en
dc.date.accessioned	2014-03-01T01:30:15Z
dc.date.available	2014-03-01T01:30:15Z
dc.date.issued	2009	en
dc.identifier.issn	1744-9081	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19523
dc.subject	Activity Pattern	en
dc.subject	Brain Activation	en
dc.subject	Event Related Potential	en
dc.subject	event-related potential erp	en
dc.subject	Executive Function	en
dc.subject	Frontal Lobe	en
dc.subject	Initial Condition	en
dc.subject	Right Hemisphere	en
dc.subject	Working Memory	en
dc.subject	Young Adult	en
dc.subject	Left Handed	en
dc.subject	Low Resolution	en
dc.subject.classification	Behavioral Sciences	en
dc.subject.classification	Neurosciences	en
dc.subject.other	WORKING-MEMORY TASK	en
dc.subject.other	FUNCTIONAL-ANATOMY	en
dc.subject.other	LANGUAGE LATERALIZATION	en
dc.subject.other	EXECUTIVE FUNCTIONS	en
dc.subject.other	PREFRONTAL CORTEX	en
dc.subject.other	FRONTAL LOBES	en
dc.subject.other	HUMAN BRAIN	en
dc.subject.other	SUPPRESSION	en
dc.subject.other	COMPREHENSION	en
dc.subject.other	PERFORMANCE	en
dc.title	Effect of initiation-inhibition and handedness on the patterns of the P50 event-related potential component: a low resolution electromagnetic tomography study	en
heal.type	journalArticle	en
heal.identifier.primary	10.1186/1744-9081-5-51	en
heal.identifier.secondary	http://dx.doi.org/10.1186/1744-9081-5-51	en
heal.identifier.secondary	51	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Background: Recent research recognizes the association between handedness, linguistic processes and cerebral networks subserving executive functioning, but the nature of this association remains unclear. Since the P50 event related potential (ERP) is considered to reflect thalamocortical processes in association with working memory (WM) operation the present study focuses on P50 patterns elicited during the performance of a linguistic related executive functioning test in right-and left-handers. Methods: In 64 young adults with a high educational level (33 left-handed) the P50 event-related potential was recorded while performing the initiation and inhibition condition of a modified version of the Hayling Sentence Completion test adjusted to induce WM. The manual preference of the participants was evaluated with the use of the Edinburgh Handedness Inventory (EHI). Results: P50 showed greater amplitudes in left-than in right-handers, mainly in frontal leads, in the initiation condition. Reduced amplitudes in inhibition compared to initiation condition were observed in left-handers. Low Resolution Electromagnetic Tomography (LORETA) analysis showed lower frontal lobe activation in the inhibition than in the initiation condition in both right-and left-handers. Also, LORETA yielded that right-handers exhibited greater activation in the inhibition condition than left-handers. Additionally, LORETA showed assymetrical hemispheric activation patterns in right-handers, in contrast to symmetrical patterns observed in left-handers. Higher P50 amplitudes were recorded in righthemisphere of right-handers in the initiation condition. Conclusion: Brain activation, especially the one closely related to thalamocortical function, elicited during WM operation involving initiation and inhibition processes appears to be related to handedness.	en
heal.publisher	BIOMED CENTRAL LTD	en
heal.journalName	BEHAVIORAL AND BRAIN FUNCTIONS	en
dc.identifier.doi	10.1186/1744-9081-5-51	en
dc.identifier.isi	ISI:000273532100001	en
dc.identifier.volume	5	en