Laser-induced fluorescence and reflectance spectroscopy for the discrimination of basal cell carcinoma from the surrounding normal skin tissue

Drakaki, E; Kaselouris, E; Makropoulou, M; Serafetinides, AA; Tsenga, A; Stratigos, AJ; Katsambas, AD; Antoniou, C

dc.contributor.author	Drakaki, E	en
dc.contributor.author	Kaselouris, E	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Serafetinides, AA	en
dc.contributor.author	Tsenga, A	en
dc.contributor.author	Stratigos, AJ	en
dc.contributor.author	Katsambas, AD	en
dc.contributor.author	Antoniou, C	en
dc.date.accessioned	2014-03-01T01:30:59Z
dc.date.available	2014-03-01T01:30:59Z
dc.date.issued	2009	en
dc.identifier.issn	1660-5527	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19703
dc.subject	Basal cell carcinoma detection	en
dc.subject	Diffused reflectance spectroscopy	en
dc.subject	Laser-induced fluorescence spectroscopy	en
dc.subject	Skin histopathology	en
dc.subject.classification	Dermatology	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	article	en
dc.subject.other	autofluorescence	en
dc.subject.other	basal cell carcinoma	en
dc.subject.other	cancer diagnosis	en
dc.subject.other	clinical article	en
dc.subject.other	computer program	en
dc.subject.other	diagnostic accuracy	en
dc.subject.other	ex vivo study	en
dc.subject.other	fluorescence spectroscopy	en
dc.subject.other	histopathology	en
dc.subject.other	human	en
dc.subject.other	human tissue	en
dc.subject.other	laser	en
dc.subject.other	laser induced fluorescence spectroscopy	en
dc.subject.other	priority journal	en
dc.subject.other	reflectometry	en
dc.subject.other	skin biopsy	en
dc.subject.other	Biopsy	en
dc.subject.other	Carcinoma, Basal Cell	en
dc.subject.other	Humans	en
dc.subject.other	Lasers	en
dc.subject.other	Light	en
dc.subject.other	Skin	en
dc.subject.other	Skin Neoplasms	en
dc.subject.other	Spectrometry, Fluorescence	en
dc.subject.other	Spectrum Analysis	en
dc.title	Laser-induced fluorescence and reflectance spectroscopy for the discrimination of basal cell carcinoma from the surrounding normal skin tissue	en
heal.type	journalArticle	en
heal.identifier.primary	10.1159/000211912	en
heal.identifier.secondary	http://dx.doi.org/10.1159/000211912	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	The object of this study was to investigate whether laser-induced skin autofluorescence (LIF) and/or light reflectance spectra could provide a useful contrast between basal cell carcinoma (BCC) tissues and the surrounding healthy skin. Unstained human skin samples, excised from humans undergoing biopsy examination, were irradiated with a nitrogen laser (lambda = 337 nm) for excitation of autofluorescence and a tungsten halogen lamp for the reflectance measurements. The ex vivo spectroscopic results were correlated with the histopathology images to distinguish the areas of BCC from those of the surrounding health skin. A simple spectral analysis technique was also applied for better skin diagnosis. In conclusion, it seems that LIF and reflectance spectra could be used to differentiate neoplastic from normal skin tissue using an appropriate classification model analysis. Copyright (C) 2009 S. Karger AG, Basel	en
heal.publisher	KARGER	en
heal.journalName	Skin Pharmacology and Physiology	en
dc.identifier.doi	10.1159/000211912	en
dc.identifier.isi	ISI:000265785400008	en
dc.identifier.volume	22	en
dc.identifier.issue	3	en
dc.identifier.spage	158	en
dc.identifier.epage	165	en