Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

Detsi, A; Majdalani, M; Kontogiorgis, CA; Hadjipavlou-Litina, D; Kefalas, P

dc.contributor.author	Detsi, A	en
dc.contributor.author	Majdalani, M	en
dc.contributor.author	Kontogiorgis, CA	en
dc.contributor.author	Hadjipavlou-Litina, D	en
dc.contributor.author	Kefalas, P	en
dc.date.accessioned	2014-03-01T01:31:17Z
dc.date.available	2014-03-01T01:31:17Z
dc.date.issued	2009	en
dc.identifier.issn	0968-0896	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19773
dc.subject	2′-Hydroxy-chalcones	en
dc.subject	Antioxidant	en
dc.subject	Aureusidin	en
dc.subject	Aurones	en
dc.subject	Lipid peroxidation	en
dc.subject	Soybean lipoxygenase	en
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.classification	Chemistry, Medicinal	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	aureusidin	en
dc.subject.other	aurone derivative	en
dc.subject.other	chalcone derivative	en
dc.subject.other	lipoxygenase inhibitor	en
dc.subject.other	unclassified drug	en
dc.subject.other	antioxidant activity	en
dc.subject.other	article	en
dc.subject.other	drug synthesis	en
dc.subject.other	enzyme inhibition	en
dc.subject.other	lipid peroxidation	en
dc.subject.other	nonhuman	en
dc.subject.other	soybean	en
dc.subject.other	structure activity relation	en
dc.subject.other	Antioxidants	en
dc.subject.other	Benzofurans	en
dc.subject.other	Biphenyl Compounds	en
dc.subject.other	Chalcones	en
dc.subject.other	Linoleic Acid	en
dc.subject.other	Lipoxygenase	en
dc.subject.other	Lipoxygenase Inhibitors	en
dc.subject.other	Magnetic Resonance Spectroscopy	en
dc.subject.other	Mass Spectrometry	en
dc.subject.other	Picrates	en
dc.subject.other	Glycine max	en
dc.title	Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.bmc.2009.10.002	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.bmc.2009.10.002	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	A series of 2'-hydroxy-chalcones and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach. An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition. (C) 2009 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Bioorganic and Medicinal Chemistry	en
dc.identifier.doi	10.1016/j.bmc.2009.10.002	en
dc.identifier.isi	ISI:000271521000027	en
dc.identifier.volume	17	en
dc.identifier.issue	23	en
dc.identifier.spage	8073	en
dc.identifier.epage	8085	en