Prognostic factors for the response to treatment in males with genital warts

Stefanaki, C; Hadjivassiliou, M; Katzouranis, I; Bethimoutis, G; Nicolaidou, E; Anyfantakis, V; Lagogianni, E; Caroni, C; Panagiotopoulos, A; Antoniou, C; Katsambas, A

dc.contributor.author	Stefanaki, C	en
dc.contributor.author	Hadjivassiliou, M	en
dc.contributor.author	Katzouranis, I	en
dc.contributor.author	Bethimoutis, G	en
dc.contributor.author	Nicolaidou, E	en
dc.contributor.author	Anyfantakis, V	en
dc.contributor.author	Lagogianni, E	en
dc.contributor.author	Caroni, C	en
dc.contributor.author	Panagiotopoulos, A	en
dc.contributor.author	Antoniou, C	en
dc.contributor.author	Katsambas, A	en
dc.date.accessioned	2014-03-01T01:31:42Z
dc.date.available	2014-03-01T01:31:42Z
dc.date.issued	2009	en
dc.identifier.issn	0926-9959	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/19901
dc.subject	Cryotherapy	en
dc.subject	Genital warts	en
dc.subject	HPV	en
dc.subject	Imiquimod	en
dc.subject	Podophyllinotoxin	en
dc.subject.classification	Dermatology	en
dc.subject.other	imiquimod	en
dc.subject.other	podophyllotoxin	en
dc.subject.other	virus DNA	en
dc.subject.other	adolescent	en
dc.subject.other	adult	en
dc.subject.other	age distribution	en
dc.subject.other	article	en
dc.subject.other	clinical feature	en
dc.subject.other	condyloma acuminatum	en
dc.subject.other	cryotherapy	en
dc.subject.other	diagnostic value	en
dc.subject.other	disease duration	en
dc.subject.other	disease severity	en
dc.subject.other	DNA determination	en
dc.subject.other	educational status	en
dc.subject.other	follow up	en
dc.subject.other	human	en
dc.subject.other	infection risk	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	mixed infection	en
dc.subject.other	priority journal	en
dc.subject.other	prognosis	en
dc.subject.other	sexual orientation	en
dc.subject.other	treatment response	en
dc.subject.other	urethra	en
dc.subject.other	Wart virus	en
dc.subject.other	Adolescent	en
dc.subject.other	Adult	en
dc.subject.other	Aminoquinolines	en
dc.subject.other	Anus Diseases	en
dc.subject.other	Combined Modality Therapy	en
dc.subject.other	Condylomata Acuminata	en
dc.subject.other	Cryotherapy	en
dc.subject.other	Genital Diseases, Male	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Podophyllotoxin	en
dc.subject.other	Prognosis	en
dc.title	Prognostic factors for the response to treatment in males with genital warts	en
heal.type	journalArticle	en
heal.identifier.primary	10.1111/j.1468-3083.2009.03270.x	en
heal.identifier.secondary	http://dx.doi.org/10.1111/j.1468-3083.2009.03270.x	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Background Factors predicting an unfavourable course of genital warts to treatment have not been determined. Materials and methods Behavioural and baseline disease characteristics were recorded from 246 males with anogenital warts. Urethral swabs were obtained and examined using the Hybrid Capture 2 Microplate assay. Patients were treated for their anogenital warts with cryotherapy, imiquimod cream 5% or podophyllotoxin. They were followed up every 3 months for 1 year. Results Patients with a negative or low-risk initial test tended to respond earlier to treatment than those with a high/intermediate-risk human papillomavirus (HPV) or with a dual infection (P = 0.028). The response rate was unrelated (P > 0.05) to the duration, number and anatomical location of the lesions and to the patient's age and sexual orientation, and only marginally to the initial extent of the lesion (P = 0.046). However, the type of treatment predicted a favourable response (P ≤ 0.001), with patients who received both imiquimod and crotherapy responding worse. Considering all factors simultaneously in logistic regression, only the type of treatment and extent of the disease were found to influence the response rate. Conclusion The type of treatment and extent of the disease were the only factors found critical for patients' response. © 2009 European Academy of Dermatology and Venereology.	en
heal.publisher	WILEY-BLACKWELL PUBLISHING, INC	en
heal.journalName	Journal of the European Academy of Dermatology and Venereology	en
dc.identifier.doi	10.1111/j.1468-3083.2009.03270.x	en
dc.identifier.isi	ISI:000269730400007	en
dc.identifier.volume	23	en
dc.identifier.issue	10	en
dc.identifier.spage	1156	en
dc.identifier.epage	1160	en