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Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

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dc.contributor.author Melagraki, G en
dc.contributor.author Afantitis, A en
dc.contributor.author Igglessi-Markopoulou, O en
dc.contributor.author Detsi, A en
dc.contributor.author Koufaki, M en
dc.contributor.author Kontogiorgis, C en
dc.contributor.author Hadjipavlou-Litina, DJ en
dc.date.accessioned 2014-03-01T01:32:01Z
dc.date.available 2014-03-01T01:32:01Z
dc.date.issued 2009 en
dc.identifier.issn 0223-5234 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/20022
dc.subject Anti-inflammatory en
dc.subject Antioxidant en
dc.subject Coumarins en
dc.subject Lipoic acid en
dc.subject.classification Chemistry, Medicinal en
dc.subject.other antiinflammatory agent en
dc.subject.other antioxidant en
dc.subject.other lipoxygenase en
dc.subject.other n(2 aminoethyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(2 aminoethyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(2 aminophenyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(2 aminophenyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(6 aminohexyl) 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(8 aminooctyl) 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n(8 octylamino) 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n[2 [4 (1,2 dithiolan 3 yl)butanamido]ethyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n[2 [4 (1,2 dithiolan 3 yl)butanamido]ethyl] 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n[6 [5 (1,2 dithiolan 3 yl)pentanamido]hexyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n[8 [5 (1,2 dithiolan 3 yl)pentanamido]octyl] 4 hydroxy 2 oxo 2h chromene 3 carboxamide en
dc.subject.other n[8 [5 (1,2 dithiolan 3 yl)pentanamido]octyl] 4 hydroxy 6 methyl 2 oxo 2h chromene 3 carboxamide en
dc.subject.other thioctic acid en
dc.subject.other unclassified drug en
dc.subject.other animal experiment en
dc.subject.other animal model en
dc.subject.other antiinflammatory activity en
dc.subject.other antioxidant activity en
dc.subject.other article en
dc.subject.other controlled study en
dc.subject.other drug design en
dc.subject.other drug screening en
dc.subject.other drug synthesis en
dc.subject.other edema en
dc.subject.other enzyme inhibition en
dc.subject.other female en
dc.subject.other mouse en
dc.subject.other nonhuman en
dc.subject.other paw edema en
dc.subject.other rat en
dc.subject.other structure activity relation en
dc.subject.other Animals en
dc.subject.other Anti-Inflammatory Agents en
dc.subject.other Antioxidants en
dc.subject.other Coumarins en
dc.subject.other Edema en
dc.subject.other Female en
dc.subject.other Lipoxygenase en
dc.subject.other Lipoxygenase Inhibitors en
dc.subject.other Male en
dc.subject.other Rats en
dc.subject.other Soybeans en
dc.subject.other Thioctic Acid en
dc.title Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.ejmech.2008.12.027 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.ejmech.2008.12.027 en
heal.language English en
heal.publicationDate 2009 en
heal.abstract In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity. (C) 2009 Elsevier Masson SAS. All rights reserved. en
heal.publisher ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER en
heal.journalName European Journal of Medicinal Chemistry en
dc.identifier.doi 10.1016/j.ejmech.2008.12.027 en
dc.identifier.isi ISI:000266524900032 en
dc.identifier.volume 44 en
dc.identifier.issue 7 en
dc.identifier.spage 3020 en
dc.identifier.epage 3026 en


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