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The effect of remifentanil on respiratory variability, evaluated with dynamic modeling

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dc.contributor.author Mitsis, GD en
dc.contributor.author Governo, RJM en
dc.contributor.author Rogers, R en
dc.contributor.author Pattinson, KTS en
dc.date.accessioned 2014-03-01T01:32:08Z
dc.date.available 2014-03-01T01:32:08Z
dc.date.issued 2009 en
dc.identifier.issn 8750-7587 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/20047
dc.subject Chemoreflex en
dc.subject Nonlinear models en
dc.subject Opioid en
dc.subject Ventilation en
dc.subject Volterra kernels en
dc.subject.classification Physiology en
dc.subject.classification Sport Sciences en
dc.subject.other remifentanil en
dc.subject.other carbon dioxide en
dc.subject.other narcotic analgesic agent en
dc.subject.other oxygen en
dc.subject.other piperidine derivative en
dc.subject.other adult en
dc.subject.other article en
dc.subject.other brain tissue en
dc.subject.other breathing mechanics en
dc.subject.other breathing pattern en
dc.subject.other breathing rate en
dc.subject.other dose response en
dc.subject.other drug brain level en
dc.subject.other drug effect en
dc.subject.other drug infusion en
dc.subject.other end tidal carbon dioxide tension en
dc.subject.other female en
dc.subject.other human en
dc.subject.other human experiment en
dc.subject.other low drug dose en
dc.subject.other lung model en
dc.subject.other male en
dc.subject.other nausea en
dc.subject.other normal human en
dc.subject.other priority journal en
dc.subject.other respiration control en
dc.subject.other respiratory tract parameters en
dc.subject.other steady state en
dc.subject.other tidal volume en
dc.subject.other algorithm en
dc.subject.other blood en
dc.subject.other heart rate en
dc.subject.other nonlinear system en
dc.subject.other physiology en
dc.subject.other reflex en
dc.subject.other statistical model en
dc.subject.other Adult en
dc.subject.other Algorithms en
dc.subject.other Analgesics, Opioid en
dc.subject.other Carbon Dioxide en
dc.subject.other Female en
dc.subject.other Heart Rate en
dc.subject.other Humans en
dc.subject.other Linear Models en
dc.subject.other Male en
dc.subject.other Models, Statistical en
dc.subject.other Nonlinear Dynamics en
dc.subject.other Oxygen en
dc.subject.other Piperidines en
dc.subject.other Reflex en
dc.subject.other Respiratory Mechanics en
dc.subject.other Young Adult en
dc.title The effect of remifentanil on respiratory variability, evaluated with dynamic modeling en
heal.type journalArticle en
heal.identifier.primary 10.1152/japplphysiol.90769.2008 en
heal.identifier.secondary http://dx.doi.org/10.1152/japplphysiol.90769.2008 en
heal.language English en
heal.publicationDate 2009 en
heal.abstract Mitsis GD, Governo RJ, Rogers R, Pattinson KT. The effect of remifentanil on respiratory variability, evaluated with dynamic modeling. J Appl Physiol 106: 1038-1049, 2009. First published February 5, 2009; doi:10.1152/japplphysiol.90769.2008.-Opioid drugs disrupt signaling in the brain stem respiratory network affecting respiratory rhythm. We evaluated the influence of a steady-state infusion of a model opioid, remifentanil, on respiratory variability during spontaneous respiration in a group of 11 healthy human volunteers. We used dynamic linear and nonlinear models to examine the effects of remifentanil on both directions of the ventilatory loop, i.e., on the influence of natural variations in end-tidal carbon dioxide (PETCO2) on ventilatory variability, which was assessed by tidal volume (VT) and breath-to-breath ventilation (i.e., the ratio of tidal volume over total breath time VT/TTOT), and vice versa. Breath-by-breath recordings of expired CO2 and respiration were made during a target-controlled infusion of remifentanil for 15 min at estimated effect site (i.e., brain tissue) concentrations of 0, 0.7, 1.1, and 1.5 ng/ml, respectively. Remifentanil caused a profound increase in the duration of expiration. The obtained models revealed a decrease in the strength of the dynamic effect of PETCO2 variability on VT (the "controller" part of the ventilatory loop) and a more pronounced increase in the effect of VT variability on PETCO2 (the "plant" part of the loop). Nonlinear models explained these dynamic interrelationships better than linear models. Our approach allows detailed investigation of drug effects in the resting state at the systems level using noninvasive and minimally perturbing experimental protocols, which can closely represent real-life clinical situations. en
heal.publisher AMER PHYSIOLOGICAL SOC en
heal.journalName Journal of Applied Physiology en
dc.identifier.doi 10.1152/japplphysiol.90769.2008 en
dc.identifier.isi ISI:000264753000005 en
dc.identifier.volume 106 en
dc.identifier.issue 4 en
dc.identifier.spage 1038 en
dc.identifier.epage 1049 en


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