UniMaP: Finding unique mass and peptide signatures in the human proteome

Alexandridou, A; Tsangaris, GTh; Vougas, K; Nikita, K; Spyrou, G

dc.contributor.author	Alexandridou, A	en
dc.contributor.author	Tsangaris, GTh	en
dc.contributor.author	Vougas, K	en
dc.contributor.author	Nikita, K	en
dc.contributor.author	Spyrou, G	en
dc.date.accessioned	2014-03-01T01:32:17Z
dc.date.available	2014-03-01T01:32:17Z
dc.date.issued	2009	en
dc.identifier.issn	1367-4803	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20097
dc.subject.classification	Biochemical Research Methods	en
dc.subject.classification	Biotechnology & Applied Microbiology	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Mathematical & Computational Biology	en
dc.subject.classification	Statistics & Probability	en
dc.subject.other	cathepsin B	en
dc.subject.other	proteome	en
dc.subject.other	von Willebrand factor	en
dc.subject.other	amino acid sequence	en
dc.subject.other	article	en
dc.subject.other	bioinformatics	en
dc.subject.other	data analysis software	en
dc.subject.other	information retrieval	en
dc.subject.other	Internet	en
dc.subject.other	molecular weight	en
dc.subject.other	nucleotide sequence	en
dc.subject.other	priority journal	en
dc.subject.other	protein analysis	en
dc.subject.other	protein database	en
dc.subject.other	proteomics	en
dc.subject.other	SWISS-PROT	en
dc.subject.other	Computational Biology	en
dc.subject.other	Humans	en
dc.subject.other	Internet	en
dc.subject.other	Peptides	en
dc.subject.other	Proteins	en
dc.subject.other	Proteome	en
dc.subject.other	Proteomics	en
dc.subject.other	Software	en
dc.title	UniMaP: Finding unique mass and peptide signatures in the human proteome	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/bioinformatics/btp516	en
heal.identifier.secondary	http://dx.doi.org/10.1093/bioinformatics/btp516	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Summary: The uniqueness of a measured molecular mass or peptide sequence plays a very important role in the fields of protein identification and peptide/protein-biomarker investigation. We present a publicly available web application that offers information concerning the uniqueness of one or more molecular masses and one or more peptide sequences in the human proteome. When a sequence is found to be unique in humans, the application is able to search across all species querying whether this sequence is unique, not only in humans but also in other species found in the Swiss-Prot Database. The application is also able to search for unique protein fragments derived computationally from enzymatic digestion driven by certain enzymes. Furthermore, the application can list all the unique masses and peptides of a given protein. Through this application, researchers are able to find unique tags, either on a molecular mass level or on a sequence level. These unique tags are remarkably important in research related to protein identification or biomarker discovery and measurements. © The Author 2009. Published by Oxford University Press. All rights reserved.	en
heal.publisher	OXFORD UNIV PRESS	en
heal.journalName	Bioinformatics	en
dc.identifier.doi	10.1093/bioinformatics/btp516	en
dc.identifier.isi	ISI:000271564300023	en
dc.identifier.volume	25	en
dc.identifier.issue	22	en
dc.identifier.spage	3035	en
dc.identifier.epage	3037	en