A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity

Roussaki, M; Kontogiorgis, CA; Hadjipavlou-Litina, D; Hamilakis, S; Detsi, A

dc.contributor.author	Roussaki, M	en
dc.contributor.author	Kontogiorgis, CA	en
dc.contributor.author	Hadjipavlou-Litina, D	en
dc.contributor.author	Hamilakis, S	en
dc.contributor.author	Detsi, A	en
dc.date.accessioned	2014-03-01T01:32:29Z
dc.date.available	2014-03-01T01:32:29Z
dc.date.issued	2010	en
dc.identifier.issn	0960-894X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20162
dc.subject	3-Aryl-coumarins	en
dc.subject	Antioxidant	en
dc.subject	Lipoxygenase	en
dc.subject.classification	Chemistry, Medicinal	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	1,1 diphenyl 2 picrylhydrazyl	en
dc.subject.other	acetophenone derivative	en
dc.subject.other	antiinflammatory agent	en
dc.subject.other	antioxidant	en
dc.subject.other	coumarin derivative	en
dc.subject.other	lipoxygenase	en
dc.subject.other	phenylacetic acid derivative	en
dc.subject.other	salicylaldehyde	en
dc.subject.other	aldol reaction	en
dc.subject.other	antiinflammatory activity	en
dc.subject.other	antioxidant activity	en
dc.subject.other	article	en
dc.subject.other	chemical reaction	en
dc.subject.other	drug activity	en
dc.subject.other	drug inhibition	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	in vitro study	en
dc.subject.other	lipid peroxidation	en
dc.subject.other	methodology	en
dc.subject.other	nonhuman	en
dc.subject.other	soybean	en
dc.subject.other	Antioxidants	en
dc.subject.other	Coumarins	en
dc.subject.other	Dose-Response Relationship, Drug	en
dc.subject.other	Lipoxygenase	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Soybeans	en
dc.subject.other	Stereoisomerism	en
dc.subject.other	Structure-Activity Relationship	en
dc.subject.other	Glycine max	en
dc.title	A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.bmcl.2010.05.022	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.bmcl.2010.05.022	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity. (c) 2010 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Bioorganic and Medicinal Chemistry Letters	en
dc.identifier.doi	10.1016/j.bmcl.2010.05.022	en
dc.identifier.isi	ISI:000278644700012	en
dc.identifier.volume	20	en
dc.identifier.issue	13	en
dc.identifier.spage	3889	en
dc.identifier.epage	3892	en