A pilot finite element study of an osteoporotic L1-vertebra compared to one with normal T-score

Provatidis, C; Vossou, C; Koukoulis, I; Balanika, A; Baltas, C; Lyritis, G

dc.contributor.author	Provatidis, C	en
dc.contributor.author	Vossou, C	en
dc.contributor.author	Koukoulis, I	en
dc.contributor.author	Balanika, A	en
dc.contributor.author	Baltas, C	en
dc.contributor.author	Lyritis, G	en
dc.date.accessioned	2014-03-01T01:32:30Z
dc.date.available	2014-03-01T01:32:30Z
dc.date.issued	2010	en
dc.identifier.issn	1025-5842	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20165
dc.subject	Biomechanics	en
dc.subject	Finite element analysis	en
dc.subject	Medical imaging	en
dc.subject	Osteoporosis	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	biological model	en
dc.subject.other	biomechanics	en
dc.subject.other	biomedical engineering	en
dc.subject.other	bone density	en
dc.subject.other	comparative study	en
dc.subject.other	computer assisted tomography	en
dc.subject.other	computer simulation	en
dc.subject.other	female	en
dc.subject.other	finite element analysis	en
dc.subject.other	fragility fracture	en
dc.subject.other	human	en
dc.subject.other	lumbar vertebra	en
dc.subject.other	pathology	en
dc.subject.other	pathophysiology	en
dc.subject.other	physiology	en
dc.subject.other	pilot study	en
dc.subject.other	postmenopause osteoporosis	en
dc.subject.other	radiography	en
dc.subject.other	reference value	en
dc.subject.other	risk factor	en
dc.subject.other	weight bearing	en
dc.subject.other	Young modulus	en
dc.subject.other	Aged	en
dc.subject.other	Biomechanics	en
dc.subject.other	Biomedical Engineering	en
dc.subject.other	Bone Density	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Elastic Modulus	en
dc.subject.other	Female	en
dc.subject.other	Finite Element Analysis	en
dc.subject.other	Humans	en
dc.subject.other	Lumbar Vertebrae	en
dc.subject.other	Models, Biological	en
dc.subject.other	Osteoporosis, Postmenopausal	en
dc.subject.other	Osteoporotic Fractures	en
dc.subject.other	Pilot Projects	en
dc.subject.other	Reference Values	en
dc.subject.other	Risk Factors	en
dc.subject.other	Tomography, X-Ray Computed	en
dc.subject.other	Weight-Bearing	en
dc.title	A pilot finite element study of an osteoporotic L1-vertebra compared to one with normal T-score	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/10255840903099703	en
heal.identifier.secondary	http://dx.doi.org/10.1080/10255840903099703	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	In this paper, two patient-specific finite element (FE) models of both an L1 vertebra with a normal T-score and a mildly wedging, osteoporotic one were created and analysed under usual action. Utilising commercial software packages for image processing and FE analysis (FEA) along with in house computer codes for a posteriori assignment of material properties, in vivo high-resolution spiral computed tomography of the entire vertebrae and FEAwere combined. Using the vertebra with a normal T-score as baseline it was found that the maximum value of the von Mises stress in the osteoporotic vertebra was 60% higher but still far below bone strength, while the maximum value of von Mises strain in the same vertebra was 148% higher than that of the vertebra with normal T-score. In the vertebra with normal T-score, 17% of its volume exhibited values of von Mises strain higher than the threshold of 4500mstrains, referenced by Homminga et al. as a threshold of fracture risk, while in the osteoporotic one this percentage was raised up to 37%. The results suggested that the osteoporotic vertebra is susceptible to fracture due to raised strains and not stresses. © 2010 Taylor & Francis.	en
heal.publisher	TAYLOR & FRANCIS LTD	en
heal.journalName	Computer Methods in Biomechanics and Biomedical Engineering	en
dc.identifier.doi	10.1080/10255840903099703	en
dc.identifier.isi	ISI:000276628100004	en
dc.identifier.volume	13	en
dc.identifier.issue	2	en
dc.identifier.spage	185	en
dc.identifier.epage	195	en