A population level computational model of the basal ganglia that generates parkinsonian local field potential activity

Tsirogiannis, GL; Tagaris, GA; Sakas, D; Nikita, KS

dc.contributor.author	Tsirogiannis, GL	en
dc.contributor.author	Tagaris, GA	en
dc.contributor.author	Sakas, D	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T01:32:31Z
dc.date.available	2014-03-01T01:32:31Z
dc.date.issued	2010	en
dc.identifier.issn	0340-1200	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20167
dc.subject	Basal ganglia	en
dc.subject	Beta band peak	en
dc.subject	Dopamine modulation	en
dc.subject	Local field potentials	en
dc.subject	Parkinson's disease	en
dc.subject	Population level models	en
dc.subject.classification	Computer Science, Cybernetics	en
dc.subject.classification	Neurosciences	en
dc.subject.other	Basal ganglia	en
dc.subject.other	Computational model	en
dc.subject.other	Deep brain stimulation	en
dc.subject.other	Dopaminergic modulation	en
dc.subject.other	Experimental data	en
dc.subject.other	Human subjects	en
dc.subject.other	Local field potentials	en
dc.subject.other	Parkinson's disease	en
dc.subject.other	Pathophysiological	en
dc.subject.other	Pathophysiology	en
dc.subject.other	Population levels	en
dc.subject.other	Post-synaptic potentials	en
dc.subject.other	Power spectral density function	en
dc.subject.other	Subthalamic nucleus	en
dc.subject.other	Synaptic connections	en
dc.subject.other	Time course	en
dc.subject.other	Brain	en
dc.subject.other	Independent component analysis	en
dc.subject.other	Microelectrodes	en
dc.subject.other	Modulation	en
dc.subject.other	Spectral density	en
dc.subject.other	Diseases	en
dc.subject.other	Parkinsonia	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	basal ganglion	en
dc.subject.other	biological model	en
dc.subject.other	brain depth stimulation	en
dc.subject.other	human	en
dc.subject.other	male	en
dc.subject.other	middle aged	en
dc.subject.other	parkinsonism	en
dc.subject.other	pathophysiology	en
dc.subject.other	physiology	en
dc.subject.other	synaptic potential	en
dc.subject.other	Aged	en
dc.subject.other	Basal Ganglia	en
dc.subject.other	Deep Brain Stimulation	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Models, Neurological	en
dc.subject.other	Parkinsonian Disorders	en
dc.subject.other	Synaptic Potentials	en
dc.title	A population level computational model of the basal ganglia that generates parkinsonian local field potential activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s00422-009-0360-3	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s00422-009-0360-3	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Recordings from the basal ganglia's subthalamic nucleus are acquired via microelectrodes immediately prior to the application of Deep Brain Stimulation (DBS) treatment for Parkinson's Disease (PD) to assist in the selection of the final point for the implantation of the DBS electrode. The acquired recordings reveal a persistent characteristic beta band peak in the power spectral density function of the Local Field Potential (LFP) signals. This peak is considered to lie at the core of the causality-effect relationships of the parkinsonian pathophysiology. Based on LFPs acquired from human subjects during DBS for PD, we constructed a computational model of the basal ganglia on the population level that generates LFPs to identify the critical pathophysiological alterations that lead to the expression of the beta band peak. To this end, we used experimental data reporting that the strengths of the synaptic connections are modified under dopamine depletion. The hypothesis that the altered dopaminergic modulation may affect both the amplitude and the time course of the postsynaptic potentials is validated by the model. The results suggest a pivotal role of both of these parameters to the pathophysiology of PD. © 2009 Springer-Verlag.	en
heal.publisher	SPRINGER	en
heal.journalName	Biological Cybernetics	en
dc.identifier.doi	10.1007/s00422-009-0360-3	en
dc.identifier.isi	ISI:000273786200006	en
dc.identifier.volume	102	en
dc.identifier.issue	2	en
dc.identifier.spage	155	en
dc.identifier.epage	176	en