Computational study of pulsatile blood flow in prototype vessel geometries of coronary segments

Chaniotis, AK; Kaiktsis, L; Katritsis, D; Efstathopoulos, E; Pantos, I; Marmarellis, V

dc.contributor.author	Chaniotis, AK	en
dc.contributor.author	Kaiktsis, L	en
dc.contributor.author	Katritsis, D	en
dc.contributor.author	Efstathopoulos, E	en
dc.contributor.author	Pantos, I	en
dc.contributor.author	Marmarellis, V	en
dc.date.accessioned	2014-03-01T01:33:02Z
dc.date.available	2014-03-01T01:33:02Z
dc.date.issued	2010	en
dc.identifier.issn	1120-1797	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20287
dc.subject	Bifurcating pipe	en
dc.subject	Blood flow simulation	en
dc.subject	Curved pipe	en
dc.subject	Wall shear stress	en
dc.subject.classification	Biophysics	en
dc.subject.other	von Willebrand factor	en
dc.subject.other	article	en
dc.subject.other	atherosclerosis	en
dc.subject.other	blood vessel wall	en
dc.subject.other	cell proliferation	en
dc.subject.other	coronary artery blood flow	en
dc.subject.other	flow rate	en
dc.subject.other	geometry	en
dc.subject.other	heart cycle	en
dc.subject.other	heart valve prosthesis	en
dc.subject.other	internalization	en
dc.subject.other	mathematical analysis	en
dc.subject.other	mathematical computing	en
dc.subject.other	mechanical stress	en
dc.subject.other	shear stress	en
dc.subject.other	simulation	en
dc.subject.other	thrombocyte aggregation	en
dc.subject.other	vascular disease	en
dc.subject.other	Algorithms	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Coronary Aneurysm	en
dc.subject.other	Coronary Artery Disease	en
dc.subject.other	Coronary Thrombosis	en
dc.subject.other	Coronary Vessels	en
dc.subject.other	Humans	en
dc.subject.other	Models, Cardiovascular	en
dc.subject.other	Myocardial Contraction	en
dc.subject.other	Periodicity	en
dc.subject.other	Platelet Aggregation	en
dc.subject.other	Regional Blood Flow	en
dc.subject.other	Stress, Mechanical	en
dc.subject.other	Time Factors	en
dc.subject.other	Ventricular Function	en
dc.title	Computational study of pulsatile blood flow in prototype vessel geometries of coronary segments	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ejmp.2009.03.004	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ejmp.2009.03.004	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	The spatial and temporal distributions of wall shear stress (WSS) in prototype vessel geometries of coronary segments are investigated via numerical simulation, and the potential association with vascular disease and specifically atherosclerosis and plaque rupture is discussed. In particular, simulation results of WSS spatio-temporal distributions are presented for pulsatile, non-Newtonian blood flow conditions for: (a) curved pipes with different curvatures, and (b) bifurcating pipes with different branching angles and flow division. The effects of non-Newtonian flow on WSS (compared to Newtonian flow) are found to be small at Reynolds numbers representative of blood flow in coronary arteries. Specific preferential sites of average low WSS (and likely atherogenesis) were found at the outer regions of the bifurcating branches just after the bifurcation, and at the outer-entry and inner-exit flow regions of the curved vessel segment. The drop in WSS was more dramatic at the bifurcating vessel sites (less than 5% of the pre-bifurcation value). These sites were also near rapid gradients of WSS changes in space and time a fact that increases the risk of rupture of plaque likely to develop at these sites. The time variation of the WSS spatial distributions was very rapid around the start and end of the systolic phase of the cardiac cycle, when strong fluctuations of intravascular pressure were also observed. These rapid and strong changes of WSS and pressure coincide temporally with the greatest flexion and mechanical stresses induced in the vessel wall by myocardial motion (ventricular contraction). The combination of these factors may increase the risk of plaque rupture and thrombus formation at these sites. (C) 2009 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.	en
heal.publisher	IST EDITORIALI POLGRAFICI INT	en
heal.journalName	Physica Medica	en
dc.identifier.doi	10.1016/j.ejmp.2009.03.004	en
dc.identifier.isi	ISI:000280471600004	en
dc.identifier.volume	26	en
dc.identifier.issue	3	en
dc.identifier.spage	140	en
dc.identifier.epage	156	en