Correlation of hydrolytic degradation with structure for copolyesters produced from glycolic and adipic acids

Simitzis, J; Triantou, D; Soulis, S; Triantou, K; Simitzis, Ch; Zoumpoulakis, L

dc.contributor.author	Simitzis, J	en
dc.contributor.author	Triantou, D	en
dc.contributor.author	Soulis, S	en
dc.contributor.author	Triantou, K	en
dc.contributor.author	Simitzis, Ch	en
dc.contributor.author	Zoumpoulakis, L	en
dc.date.accessioned	2014-03-01T01:33:05Z
dc.date.available	2014-03-01T01:33:05Z
dc.date.issued	2010	en
dc.identifier.issn	0957-4530	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20307
dc.subject	Ethylene Glycol	en
dc.subject	Experimental Data	en
dc.subject	Kinetics	en
dc.subject	Organic Solvent	en
dc.subject	Rate Constant	en
dc.subject	Weight Loss	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Absorption band	en
dc.subject.other	Adipates	en
dc.subject.other	Adipic acids	en
dc.subject.other	Amorphous regions	en
dc.subject.other	Biodegradable polyesters	en
dc.subject.other	Copolyesters	en
dc.subject.other	Crystalline regions	en
dc.subject.other	Experimental data	en
dc.subject.other	Four-parameter model	en
dc.subject.other	FT-IR spectrum	en
dc.subject.other	Glycolic acids	en
dc.subject.other	Homopolyesters	en
dc.subject.other	Hydrolytic degradation	en
dc.subject.other	Initial time	en
dc.subject.other	Molar ratio	en
dc.subject.other	Structural unit	en
dc.subject.other	Time periods	en
dc.subject.other	Two-parameter models	en
dc.subject.other	Weight loss	en
dc.subject.other	Esters	en
dc.subject.other	Ethylene	en
dc.subject.other	Ethylene glycol	en
dc.subject.other	Exponential functions	en
dc.subject.other	Fourier transform infrared spectroscopy	en
dc.subject.other	Hydrolysis	en
dc.subject.other	Organic solvents	en
dc.subject.other	Polyesters	en
dc.subject.other	Rate constants	en
dc.subject.other	Photodegradation	en
dc.subject.other	adipic acid	en
dc.subject.other	ethylene glycol	en
dc.subject.other	glycolic acid	en
dc.subject.other	polyester	en
dc.subject.other	article	en
dc.subject.other	biodegradability	en
dc.subject.other	chemical structure	en
dc.subject.other	controlled study	en
dc.subject.other	degradation kinetics	en
dc.subject.other	hydrolysis	en
dc.subject.other	priority journal	en
dc.subject.other	solubility	en
dc.subject.other	synthesis	en
dc.subject.other	Absorbable Implants	en
dc.subject.other	Adipic Acids	en
dc.subject.other	Biocompatible Materials	en
dc.subject.other	Biodegradation, Environmental	en
dc.subject.other	Biotransformation	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Glycolates	en
dc.subject.other	Hydrolysis	en
dc.subject.other	Materials Testing	en
dc.subject.other	Models, Statistical	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Polyesters	en
dc.subject.other	Spectroscopy, Fourier Transform Infrared	en
dc.subject.other	Structure-Activity Relationship	en
dc.subject.other	Surface Properties	en
dc.subject.other	Temperature	en
dc.title	Correlation of hydrolytic degradation with structure for copolyesters produced from glycolic and adipic acids	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s10856-009-3951-6	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s10856-009-3951-6	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Copolyesters based on glycolic acid (G) combined with adipic acid (A) and ethylene glycol (E) were synthesized in different percentage of molar ratios (A: 100-50% and G: 100%) and their hydrolytic degradation was studied and correlated with their structures. According to the DSC, the production of polyesters leads to the formation of copolyesters and not to mixtures of homopolyesters. The crystallites in the copolyesters mainly consist of continuous sequences of ethylene adipate structural units. The hydrolytic degradation of the polyesters was followed by their weight loss during hydrolysis and by the FTIR spectra of the initial polyesters compared with that of the degraded polyesters at equilibrium. The region between 1142 and 800 cm-1 can be utilized to evaluate the extent of degradation of polyesters after their hydrolysis. The absorption bands at 1142, 1077 and 850 cm-1 due to the amorphous region decrease after hydrolysis, whereas those at 972, 901 and 806 cm-1 due to the crystalline region increase. The experimental data of the hydrolytic degradation were fitted with exponential rise to maximum type functions using two-parameter model, which describes very well mainly the initial part of the degradation, and four-parameter model (containing two exponential terms), which is appropriate for fitting the hydrolytic degradation on the entire time period (including the equilibrium). Furthermore, the kinetics of the hydrolytic degradation of the polyesters for the initial time period based on both models results to similar values of the rate constant, k. The synthesized copolyesters of glycolic acid combined with adipic acid and ethylene glycol are soluble in many common organic solvents opposite to PGA, leading to modified biodegradable polyesters and therefore they can be easily processed. © 2009 Springer Science+Business Media, LLC.	en
heal.publisher	SPRINGER	en
heal.journalName	Journal of Materials Science: Materials in Medicine	en
dc.identifier.doi	10.1007/s10856-009-3951-6	en
dc.identifier.isi	ISI:000276275600004	en
dc.identifier.volume	21	en
dc.identifier.issue	4	en
dc.identifier.spage	1069	en
dc.identifier.epage	1079	en