Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye

Ninawe, PR; Hatziavramidis, D; Parulekar, SJ

dc.contributor.author	Ninawe, PR	en
dc.contributor.author	Hatziavramidis, D	en
dc.contributor.author	Parulekar, SJ	en
dc.date.accessioned	2014-03-01T01:33:07Z
dc.date.available	2014-03-01T01:33:07Z
dc.date.issued	2010	en
dc.identifier.issn	0009-2509	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20326
dc.subject	Anti-VEGF agent	en
dc.subject	Drug macromolecule	en
dc.subject	Ocular drug delivery	en
dc.subject	Sclera permeability	en
dc.subject	Sustained delivery	en
dc.subject	Thermally responsive gel	en
dc.subject.classification	Engineering, Chemical	en
dc.subject.other	Anti-VEGF agent	en
dc.subject.other	Ocular drug delivery	en
dc.subject.other	Sclera permeability	en
dc.subject.other	Sustained delivery	en
dc.subject.other	Thermally responsive	en
dc.subject.other	Acrylic monomers	en
dc.subject.other	Amides	en
dc.subject.other	Drug delivery	en
dc.subject.other	Macromolecules	en
dc.subject.other	Phase transitions	en
dc.subject.other	Gels	en
dc.title	Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ces.2010.06.014	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ces.2010.06.014	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the posterior eye from an implant, made of poly(N-isopropylacrylamide) (NIPAM) and placed episclerally, is presented. The thermally sensitive gel is modelled as a poroelastic material with a phase transition characterized by a lower critical solution temperature (LCST). The study utilizes compartments for various eye tissues, with individual compartments considered to be completely mixed and drug transport between compartments occurring by one-dimensional diffusion. (C) 2010 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Chemical Engineering Science	en
dc.identifier.doi	10.1016/j.ces.2010.06.014	en
dc.identifier.isi	ISI:000280660400010	en
dc.identifier.volume	65	en
dc.identifier.issue	18	en
dc.identifier.spage	5170	en
dc.identifier.epage	5177	en