Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery

Felekis, D; Eleftheriadou, A; Papadakos, G; Bosinakou, I; Ferekidou, E; Kandiloros, D; Katsaragakis, S; Charalabopoulos, K; Manolopoulos, L

dc.contributor.author	Felekis, D	en
dc.contributor.author	Eleftheriadou, A	en
dc.contributor.author	Papadakos, G	en
dc.contributor.author	Bosinakou, I	en
dc.contributor.author	Ferekidou, E	en
dc.contributor.author	Kandiloros, D	en
dc.contributor.author	Katsaragakis, S	en
dc.contributor.author	Charalabopoulos, K	en
dc.contributor.author	Manolopoulos, L	en
dc.date.accessioned	2014-03-01T01:33:18Z
dc.date.available	2014-03-01T01:33:18Z
dc.date.issued	2010	en
dc.identifier.issn	0163-5581	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20369
dc.subject.classification	Oncology	en
dc.subject.classification	Nutrition & Dietetics	en
dc.subject.other	albumin	en
dc.subject.other	arginine	en
dc.subject.other	C reactive protein	en
dc.subject.other	fibrinogen	en
dc.subject.other	interleukin 6	en
dc.subject.other	omega 3 fatty acid	en
dc.subject.other	prealbumin	en
dc.subject.other	RNA	en
dc.subject.other	tumor necrosis factor alpha	en
dc.subject.other	adult	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	clinical article	en
dc.subject.other	enteric feeding	en
dc.subject.other	female	en
dc.subject.other	head and neck cancer	en
dc.subject.other	human	en
dc.subject.other	immune response	en
dc.subject.other	inflammation	en
dc.subject.other	male	en
dc.subject.other	nutritional status	en
dc.subject.other	nutritional support	en
dc.subject.other	perioperative period	en
dc.subject.other	postoperative complication	en
dc.subject.other	postoperative period	en
dc.subject.other	squamous cell carcinoma	en
dc.subject.other	treatment outcome	en
dc.subject.other	Adult	en
dc.subject.other	Aged	en
dc.subject.other	Arginine	en
dc.subject.other	Biological Markers	en
dc.subject.other	Carcinoma, Squamous Cell	en
dc.subject.other	Double-Blind Method	en
dc.subject.other	Enteral Nutrition	en
dc.subject.other	Fatty Acids, Omega-3	en
dc.subject.other	Female	en
dc.subject.other	Food, Formulated	en
dc.subject.other	Head and Neck Neoplasms	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Malnutrition	en
dc.subject.other	Middle Aged	en
dc.subject.other	Nutritional Status	en
dc.subject.other	Perioperative Care	en
dc.subject.other	Postoperative Complications	en
dc.subject.other	RNA	en
dc.subject.other	Treatment Outcome	en
dc.title	Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/01635581.2010.494336	en
heal.identifier.secondary	http://dx.doi.org/10.1080/01635581.2010.494336	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Administration of imunno-enhanced nutritional support may decrease postoperative morbidity, mortality, and infectious complications in cancer patients. The aim of this study was to verify that perioperative enteral diet, enriched with the nutrients arginine, ribonucleic acid (RNA), and ω-3 fatty acids improves outcomes of head and neck cancer patients undergoing major surgery. Forty patients with squamous cell carcinoma of the head and neck were studied. Group 1 received no preoperative nutritional support, whereas Group 2 received an oral formula with nutrients arginine, RNA, and ω-3 fatty acids. After surgery, Group 1 received a standard enteral formula, whereas Group 2 received an enriched enteral formula. Albumin (g/dl), prealbumin, fibrinogen, CRP, Il-6, and TNFa were measured 5 days before and 8 days after surgery. No statistically significant difference was observed for all the evaluated markers between postoperative and preoperative levels for both groups. The rate of complications was significantly reduced in the total number of patients receiving immunonutrition and in the particular subgroup of well-nourished patients receiving an immuno-enhanced diet. Perioperative enteral immuno-enhanced feeding in head and neck cancer patients undergoing major surgery may influence the postoperative outcomes by reducing the frequency rate of infections and wound complications. Copyright © 2010, Taylor & Francis Group, LLC.	en
heal.publisher	LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS	en
heal.journalName	Nutrition and Cancer	en
dc.identifier.doi	10.1080/01635581.2010.494336	en
dc.identifier.isi	ISI:000283879600011	en
dc.identifier.volume	62	en
dc.identifier.issue	8	en
dc.identifier.spage	1105	en
dc.identifier.epage	1112	en