Efficient construction of functionalized 5-carboxymethyl tetramic acids using N-Ac-l-aspartic anhydride as chiral building block

Prousis, KC; Markopoulos, J; Mckee, V; Igglessi-Markopoulou, O

dc.contributor.author	Prousis, KC	en
dc.contributor.author	Markopoulos, J	en
dc.contributor.author	Mckee, V	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:33:20Z
dc.date.available	2014-03-01T01:33:20Z
dc.date.issued	2010	en
dc.identifier.issn	0040-4020	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20381
dc.subject	3,3′-Disubstituted pyrrolidine-2,4-diones	en
dc.subject	C-acylation	en
dc.subject	l-Aspartic anhydride	en
dc.subject	Lithium enolates	en
dc.subject	Tetramic acids	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	acid anhydride	en
dc.subject.other	aspartic acid	en
dc.subject.other	natural product	en
dc.subject.other	pyrrolidine derivative	en
dc.subject.other	tetramic acid derivative	en
dc.subject.other	acylation	en
dc.subject.other	article	en
dc.subject.other	chemical structure	en
dc.subject.other	chirality	en
dc.subject.other	enantiomer	en
dc.subject.other	optical rotation	en
dc.subject.other	priority journal	en
dc.subject.other	synthesis	en
dc.title	Efficient construction of functionalized 5-carboxymethyl tetramic acids using N-Ac-l-aspartic anhydride as chiral building block	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.tet.2010.03.083	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.tet.2010.03.083	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	A novel method for the synthesis of densely functionalized optically active 5-carboxymethyl tetramic acids is reported. The proposed strategy is focused on the synthesis of 3,3'-disubstituted pyrrolidine-2,4-diones as useful molecules for the synthesis of natural products. The proposed methodology has been established by X-ray diffraction structure analysis. (C) 2010 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Tetrahedron	en
dc.identifier.doi	10.1016/j.tet.2010.03.083	en
dc.identifier.isi	ISI:000278196500008	en
dc.identifier.volume	66	en
dc.identifier.issue	22	en
dc.identifier.spage	3944	en
dc.identifier.epage	3950	en