Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt

Manos, TA; Sokolis, DP; Giagini, AT; Davos, CH; Kakisis, JD; Kritharis, EP; Stergiopulos, N; Karayannacos, PE; Tsangaris, S

dc.contributor.author	Manos, TA	en
dc.contributor.author	Sokolis, DP	en
dc.contributor.author	Giagini, AT	en
dc.contributor.author	Davos, CH	en
dc.contributor.author	Kakisis, JD	en
dc.contributor.author	Kritharis, EP	en
dc.contributor.author	Stergiopulos, N	en
dc.contributor.author	Karayannacos, PE	en
dc.contributor.author	Tsangaris, S	en
dc.date.accessioned	2014-03-01T01:33:42Z
dc.date.available	2014-03-01T01:33:42Z
dc.date.issued	2010	en
dc.identifier.issn	1089-7771	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20546
dc.subject	Arteriovenous shunt	en
dc.subject	Computational fluid dynamics	en
dc.subject	Doppler ultrasound	en
dc.subject	Hemodynamics	en
dc.subject	Intimal hyperplasia	en
dc.subject	Swine model	en
dc.subject.classification	Computer Science, Information Systems	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Mathematical & Computational Biology	en
dc.subject.classification	Medical Informatics	en
dc.subject.other	Arteriovenous shunt	en
dc.subject.other	Biplane angiographies	en
dc.subject.other	Color Doppler	en
dc.subject.other	Computational model	en
dc.subject.other	Dean vortex	en
dc.subject.other	Doppler ultrasound	en
dc.subject.other	Experimental data	en
dc.subject.other	In-vivo	en
dc.subject.other	In-vivo experiments	en
dc.subject.other	Input datas	en
dc.subject.other	Intimal hyperplasia	en
dc.subject.other	Intravascular	en
dc.subject.other	Mechanical study	en
dc.subject.other	Transition lines	en
dc.subject.other	Ultrasound measurement	en
dc.subject.other	Vessel walls	en
dc.subject.other	Wall mechanics	en
dc.subject.other	Wall shear stress	en
dc.subject.other	WSS gradients	en
dc.subject.other	Computational fluid dynamics	en
dc.subject.other	Flow fields	en
dc.subject.other	Fluid dynamics	en
dc.subject.other	Fluids	en
dc.subject.other	Hydrodynamics	en
dc.subject.other	Non Newtonian flow	en
dc.subject.other	Stresses	en
dc.subject.other	Ultrasonics	en
dc.subject.other	Unsteady flow	en
dc.subject.other	Hemodynamics	en
dc.title	Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/TITB.2010.2040288	en
heal.identifier.secondary	http://dx.doi.org/10.1109/TITB.2010.2040288	en
heal.identifier.secondary	5438787	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Venous anastomotic intimal hyperplasia (IH) observed in the arteriovenous shunt (AVS) has been associated with disturbed hemodynamics. This study aims to correlate hemodynamics with wall histology and wall mechanics by examining the flow field in AVS with computational fluid dynamics using experimental data taken from in vivo experiments. Input data to the computational model were obtained in vivo one month after AVS creation; adjacent vessels were submitted to histological and mechanical examination. The 3-D shunt geometry was determined using biplane angiography. Ultrasound measurements of flow rates were performed with perivascular flow probes and pressures were recorded through intravascular catheters. These data were considered as boundary conditions for calculation of the unsteady flow field. Numerical findings are suggestive of strong Dean vortices toward bothveinflowexits, verified by color Doppler. The high wall shear stresses (WSSs) and their gradients appear to be related to areas of IH and vessel wall stiffening, as evidenced in preliminary histological and mechanical studies of the venous wall. Additionally, suture line hyperplasia seems to be aggravated by the high WSS gradients noted at the transition line from graft to vein. © 2006 IEEE.	en
heal.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC	en
heal.journalName	IEEE Transactions on Information Technology in Biomedicine	en
dc.identifier.doi	10.1109/TITB.2010.2040288	en
dc.identifier.isi	ISI:000278538300017	en
dc.identifier.volume	14	en
dc.identifier.issue	3	en
dc.identifier.spage	681	en
dc.identifier.epage	690	en