Oxidative stress and atherogenesis. An FT-IR spectroscopic study

Mamarelis, I; Pissaridi, K; Dritsa, V; Kotileas, P; Tsiligiris, V; Tzilalis, V; Anastassopoulou, J

dc.contributor.author	Mamarelis, I	en
dc.contributor.author	Pissaridi, K	en
dc.contributor.author	Dritsa, V	en
dc.contributor.author	Kotileas, P	en
dc.contributor.author	Tsiligiris, V	en
dc.contributor.author	Tzilalis, V	en
dc.contributor.author	Anastassopoulou, J	en
dc.date.accessioned	2014-03-01T01:34:03Z
dc.date.available	2014-03-01T01:34:03Z
dc.date.issued	2010	en
dc.identifier.issn	0258-851X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/20666
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-78650949350&partnerID=40&md5=fa74ea524339b36018cb0144ec9a8b34	en
dc.subject	Atheromatic plaque	en
dc.subject	Carotid	en
dc.subject	Free radicals	en
dc.subject	Infrared	en
dc.subject	Lipids	en
dc.subject	Oxidative stress	en
dc.subject	Peroxidation	en
dc.subject	SEM	en
dc.subject.classification	Medicine, Research & Experimental	en
dc.subject.other	calcium	en
dc.subject.other	copper	en
dc.subject.other	lead	en
dc.subject.other	low density lipoprotein	en
dc.subject.other	silicon	en
dc.subject.other	silver	en
dc.subject.other	titanium	en
dc.subject.other	adult	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	atherogenesis	en
dc.subject.other	atherosclerotic plaque	en
dc.subject.other	carotid atherosclerosis	en
dc.subject.other	carotid endarterectomy	en
dc.subject.other	clinical article	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	human tissue	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	male	en
dc.subject.other	oxidative stress	en
dc.subject.other	scanning electron microscopy	en
dc.subject.other	work environment	en
dc.subject.other	Aged	en
dc.subject.other	Aged, 80 and over	en
dc.subject.other	Atherosclerosis	en
dc.subject.other	Carotid Arteries	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Lipid Peroxidation	en
dc.subject.other	Male	en
dc.subject.other	Metals, Heavy	en
dc.subject.other	Middle Aged	en
dc.subject.other	Occupational Exposure	en
dc.subject.other	Oxidative Stress	en
dc.subject.other	Plaque, Atherosclerotic	en
dc.subject.other	Risk Factors	en
dc.subject.other	Smoking	en
dc.subject.other	Spectroscopy, Fourier Transform Infrared	en
dc.title	Oxidative stress and atherogenesis. An FT-IR spectroscopic study	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Atherosclerosis is a complex phenomenon which leads to sudden death. Fourier transform infrared (FT-IR) spectroscopy was used to study the pathogenic components of carotids that produce the atheromatic plaque at the molecular level, as well as the role of free radicals which are developed during oxidative stress and their effect on plaque generation. The absorption infrared spectra reflected significant changes which were analogous to clinical data of each patient. The spectra contained signature bands of the biological molecules which were characteristic for the plaque components. The hands found at about 3080 cm(-1) and 1736 cm(-1) were proportional to low-density lipoprotein concentration for each patient, suggesting the hydroperoxidation of lipids due to free radicals, generated during oxidative stress. From scanning electron microscopy analysis, it was found that the carotid plaques contained calcium minerals, silicon and heavy metals, such as copper, silver, lead and titanium, which were related to the working environment of the patients.	en
heal.publisher	INT INST ANTICANCER RESEARCH	en
heal.journalName	In Vivo	en
dc.identifier.isi	ISI:000285682100012	en
dc.identifier.volume	24	en
dc.identifier.issue	6	en
dc.identifier.spage	883	en
dc.identifier.epage	888	en