DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association

Maragkakis, M; Vergoulis, T; Alexiou, P; Reczko, M; Plomaritou, K; Gousis, M; Kourtis, K; Koziris, N; Dalamagas, T; Hatzigeorgiou, AG

dc.contributor.author	Maragkakis, M	en
dc.contributor.author	Vergoulis, T	en
dc.contributor.author	Alexiou, P	en
dc.contributor.author	Reczko, M	en
dc.contributor.author	Plomaritou, K	en
dc.contributor.author	Gousis, M	en
dc.contributor.author	Kourtis, K	en
dc.contributor.author	Koziris, N	en
dc.contributor.author	Dalamagas, T	en
dc.contributor.author	Hatzigeorgiou, AG	en
dc.date.accessioned	2014-03-01T01:35:30Z
dc.date.available	2014-03-01T01:35:30Z
dc.date.issued	2011	en
dc.identifier.issn	0305-1048	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21089
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.other	microRNA	en
dc.subject.other	article	en
dc.subject.other	bibliographic database	en
dc.subject.other	binding site	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	client server application	en
dc.subject.other	computer interface	en
dc.subject.other	computer prediction	en
dc.subject.other	Drosophila melanogaster	en
dc.subject.other	genetic association	en
dc.subject.other	Internet	en
dc.subject.other	nomenclature	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	single nucleotide polymorphism	en
dc.subject.other	web browser	en
dc.subject.other	Animals	en
dc.subject.other	Bibliography as Topic	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	Disease	en
dc.subject.other	Drosophila melanogaster	en
dc.subject.other	Genetic Association Studies	en
dc.subject.other	Humans	en
dc.subject.other	Internet	en
dc.subject.other	Mice	en
dc.subject.other	MicroRNAs	en
dc.subject.other	Software	en
dc.subject.other	Caenorhabditis elegans	en
dc.subject.other	Drosophila melanogaster	en
dc.title	DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/nar/gkr294	en
heal.identifier.secondary	http://dx.doi.org/10.1093/nar/gkr294	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	microRNAs (miRNAs) are small endogenous RNA molecules that are implicated in many biological processes through post-transcriptional regulation of gene expression. The DIANA-microT Web server provides a user-friendly interface for comprehensive computational analysis of miRNA targets in human and mouse. The server has now been extended to support predictions for two widely studied species: Drosophila melanogaster and Caenorhabditis elegans. In the updated version, the Web server enables the association of miRNAs to diseases through bibliographic analysis and provides insights for the potential involvement of miRNAs in biological processes. The nomenclature used to describe mature miRNAs along different miRBase versions has been extensively analyzed, and the naming history of each miRNA has been extracted. This enables the identification of miRNA publications regardless of possible nomenclature changes. User interaction has been further refined allowing users to save results that they wish to analyze further. A connection to the UCSC genome browser is now provided, enabling users to easily preview predicted binding sites in comparison to a wide array of genomic tracks, such as single nucleotide polymorphisms. The Web server is publicly accessible in www.microrna.gr/microT-v4. © 2011 The Author(s).	en
heal.publisher	OXFORD UNIV PRESS	en
heal.journalName	Nucleic Acids Research	en
dc.identifier.doi	10.1093/nar/gkr294	en
dc.identifier.isi	ISI:000292325300024	en
dc.identifier.volume	39	en
dc.identifier.issue	SUPPL. 2	en
dc.identifier.spage	W145	en
dc.identifier.epage	W148	en