Electrochemical study of some non-steroidal anti-inflammatory drugs: Solvent effect and antioxidant activity

Tsopelas, F; Ochsenkuhn-Petropoulou, M; Zikos, N; Spyropoulou, E; Andreadou, I; Tsantili-Kakoulidou, A

dc.contributor.author	Tsopelas, F	en
dc.contributor.author	Ochsenkuhn-Petropoulou, M	en
dc.contributor.author	Zikos, N	en
dc.contributor.author	Spyropoulou, E	en
dc.contributor.author	Andreadou, I	en
dc.contributor.author	Tsantili-Kakoulidou, A	en
dc.date.accessioned	2014-03-01T01:35:37Z
dc.date.available	2014-03-01T01:35:37Z
dc.date.issued	2011	en
dc.identifier.issn	1432-8488	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21127
dc.subject	Antioxidant activity	en
dc.subject	DPPH	en
dc.subject	Non-steroidal anti-inflammatory drugs	en
dc.subject	Oxicams	en
dc.subject	Solvent polarity effect	en
dc.subject	Voltammetry	en
dc.subject.classification	Electrochemistry	en
dc.subject.other	Antioxidant activities	en
dc.subject.other	DPPH	en
dc.subject.other	Non-steroidal anti-inflammatory drugs	en
dc.subject.other	Oxicams	en
dc.subject.other	Solvent polarity effect	en
dc.subject.other	Chronoamperometry	en
dc.subject.other	Cyclic voltammetry	en
dc.subject.other	Drug interactions	en
dc.subject.other	Electrochemical oxidation	en
dc.subject.other	Glass membrane electrodes	en
dc.subject.other	Glassy carbon	en
dc.subject.other	Reaction intermediates	en
dc.subject.other	Reaction rates	en
dc.subject.other	Solvents	en
dc.title	Electrochemical study of some non-steroidal anti-inflammatory drugs: Solvent effect and antioxidant activity	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s10008-010-1165-y	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s10008-010-1165-y	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	The electrochemical behavior of 12 non-steroidal anti-inflammatory drugs (NSAIDs) was studied by means of cyclic voltammetry at a glassy carbon electrode. The underlying solvent had a considerable effect to the oxidation potentials of the investigated NSAIDs due to the alteration of their polar intermediates' solvation. Oxicams were more capable of electrochemical oxidation, and the influence of both specific and non-specific solute-solvent interactions in their reactivity was confirmed by means of Kamlet-Taft's analysis. Oxicams were further studied by chronoamperometry at the potentials of 300, 500, and 800 mV. The results obtained by the employed electroanalytical techniques were compared with the reactivity of oxicams towards 1,1- diphenyl-2-dipicrylhydrazyl (DPPH). The study showed a correlation of oxicams' amperometric signal at 800 mV with their absolute reaction rate, z with DPPH. © 2010 Springer-Verlag.	en
heal.publisher	SPRINGER	en
heal.journalName	Journal of Solid State Electrochemistry	en
dc.identifier.doi	10.1007/s10008-010-1165-y	en
dc.identifier.isi	ISI:000290544100003	en
dc.identifier.volume	15	en
dc.identifier.issue	6	en
dc.identifier.spage	1099	en
dc.identifier.epage	1108	en