Protective effect of Sideritis euboea extract on bone mineral density and strength of ovariectomized rats

Dontas, IA; Lelovas, PP; Kourkoulis, SK; Aligiannis, N; Paliogianni, A; Mitakou, S; Galanos, A; Kassi, E; Mitousoudis, A; Xanthos, TT; Papaioannou, N; Lyritis, GP

dc.contributor.author	Dontas, IA	en
dc.contributor.author	Lelovas, PP	en
dc.contributor.author	Kourkoulis, SK	en
dc.contributor.author	Aligiannis, N	en
dc.contributor.author	Paliogianni, A	en
dc.contributor.author	Mitakou, S	en
dc.contributor.author	Galanos, A	en
dc.contributor.author	Kassi, E	en
dc.contributor.author	Mitousoudis, A	en
dc.contributor.author	Xanthos, TT	en
dc.contributor.author	Papaioannou, N	en
dc.contributor.author	Lyritis, GP	en
dc.date.accessioned	2014-03-01T01:36:41Z
dc.date.available	2014-03-01T01:36:41Z
dc.date.issued	2011	en
dc.identifier.issn	1072-3714	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21395
dc.subject	Bone mineral density	en
dc.subject	Dual-energy X-ray absorptiometry	en
dc.subject	Osteoporosis	en
dc.subject	Ovariectomy	en
dc.subject	Rat	en
dc.subject	Three-point-bending	en
dc.subject.classification	Obstetrics & Gynecology	en
dc.subject.other	plant extract	en
dc.subject.other	Sideritis euboea extract	en
dc.subject.other	unclassified drug	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	biomechanics	en
dc.subject.other	body weight	en
dc.subject.other	bone density	en
dc.subject.other	bone strength	en
dc.subject.other	controlled study	en
dc.subject.other	drug effect	en
dc.subject.other	female	en
dc.subject.other	femur	en
dc.subject.other	medicinal plant	en
dc.subject.other	metaphysis	en
dc.subject.other	nonhuman	en
dc.subject.other	osteolysis	en
dc.subject.other	osteoporosis	en
dc.subject.other	ovariectomy	en
dc.subject.other	rat	en
dc.subject.other	Sideritis euboea	en
dc.subject.other	tibia	en
dc.subject.other	uterus weight	en
dc.subject.other	Animals	en
dc.subject.other	Biomechanics	en
dc.subject.other	Bone Density	en
dc.subject.other	Compressive Strength	en
dc.subject.other	Disease Models, Animal	en
dc.subject.other	Humans	en
dc.subject.other	Osteoporosis	en
dc.subject.other	Ovariectomy	en
dc.subject.other	Phytotherapy	en
dc.subject.other	Plant Extracts	en
dc.subject.other	Random Allocation	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Wistar	en
dc.subject.other	Sideritis	en
dc.title	Protective effect of Sideritis euboea extract on bone mineral density and strength of ovariectomized rats	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/gme.0b013e31820ce580	en
heal.identifier.secondary	http://dx.doi.org/10.1097/gme.0b013e31820ce580	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	Objective: The aim of this study was to investigate the potential protective effect of Sideritis euboea extract (SID), commonly consumed as ""mountain tea,"" on bone mineral density (BMD) and the strength of the ovariectomized (OVX) rat model of osteoporosis. Methods: Thirty-two 10-month-old Wistar rats were separated into controls (sham operated), OVX, and OVX plus SID in their drinking water (dose, 330 mg/kg body weight per day), starting immediately after OVX for 6 months. Tibial BMD at baseline and at 3 and 6 months post-OVX, three-point-bending of the femur, and body and uterine weight at the study end were examined. Results: BMD percentage change from baseline of the whole tibia was similar in control and OVX + SID rats at 3 months (-3.02% vs-4.67%, P = not significant), revealing a strong osteoprotective effect. At 6 months, the corresponding changes were-6.02% versus-14.37%, P < 0.05, indicating a greater bone loss in treated rats, albeit significantly less than the OVX change (-20.46%; OVX vs OVX + SID, P < 0.05). The proximal (metaphyseal) tibial BMD percentage change from baseline to 3 and 6 months between the OVX and OVX + SID groups (-26.47% vs-15.57% and-31.22% vs-16.57%, respectively) was statistically significant, demonstrating that SID preserved the proximal tibial BMD of the OVX + SID group significantly. Three-point-bending showed a significant increase in the treated compared with the OVX groups. Body and uterine weights were similar in the OVX and treated groups. Conclusions: SID significantly protected tibial bone loss and improved femoral biomechanical strength in OVX + SID rats compared with OVX rats. © 2011 by The North American Menopause Society.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	Menopause	en
dc.identifier.doi	10.1097/gme.0b013e31820ce580	en
dc.identifier.isi	ISI:000293174200017	en
dc.identifier.volume	18	en
dc.identifier.issue	8	en
dc.identifier.spage	915	en
dc.identifier.epage	922	en