Ruthenium-catalyzed selective hydrogenation of bis-arylidene tetramic acids. Application to the synthesis of novel structurally diverse pyrrolidine-2,4-diones

Karaiskos, CS; Matiadis, D; Markopoulos, J; Igglessi-Markopoulou, O

dc.contributor.author	Karaiskos, CS	en
dc.contributor.author	Matiadis, D	en
dc.contributor.author	Markopoulos, J	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:36:43Z
dc.date.available	2014-03-01T01:36:43Z
dc.date.issued	2011	en
dc.identifier.issn	1420-3049	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21413
dc.subject	Arylidenetetramic acid	en
dc.subject	BINAP	en
dc.subject	Homogeneous catalysis	en
dc.subject	Hydrogenation	en
dc.subject	Ruthenium catalysts	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	2 pyrrolidone derivative	en
dc.subject.other	pyrrolidine	en
dc.subject.other	pyrrolidine derivative	en
dc.subject.other	ruthenium	en
dc.subject.other	tetramic acid	en
dc.subject.other	article	en
dc.subject.other	catalysis	en
dc.subject.other	chemistry	en
dc.subject.other	hydrogenation	en
dc.subject.other	stereoisomerism	en
dc.subject.other	Catalysis	en
dc.subject.other	Hydrogenation	en
dc.subject.other	Pyrrolidines	en
dc.subject.other	Pyrrolidinones	en
dc.subject.other	Ruthenium	en
dc.subject.other	Stereoisomerism	en
dc.title	Ruthenium-catalyzed selective hydrogenation of bis-arylidene tetramic acids. Application to the synthesis of novel structurally diverse pyrrolidine-2,4-diones	en
heal.type	journalArticle	en
heal.identifier.primary	10.3390/molecules16076116	en
heal.identifier.secondary	http://dx.doi.org/10.3390/molecules16076116	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data. © 2011 by the authors; licensee MDPI, Basel, Switzerland.	en
heal.publisher	MDPI AG	en
heal.journalName	Molecules	en
dc.identifier.doi	10.3390/molecules16076116	en
dc.identifier.isi	ISI:000293073900060	en
dc.identifier.volume	16	en
dc.identifier.issue	7	en
dc.identifier.spage	6116	en
dc.identifier.epage	6128	en