Sacrificial template-directed fabrication of superparamagnetic polymer microcontainers for pH-activated controlled release of Daunorubicin

Chatzipavlidis, A; Bilalis, P; Efthimiadou, EK; Boukos, N; Kordas, GC

dc.contributor.author	Chatzipavlidis, A	en
dc.contributor.author	Bilalis, P	en
dc.contributor.author	Efthimiadou, EK	en
dc.contributor.author	Boukos, N	en
dc.contributor.author	Kordas, GC	en
dc.date.accessioned	2014-03-01T01:36:43Z
dc.date.available	2014-03-01T01:36:43Z
dc.date.issued	2011	en
dc.identifier.issn	0743-7463	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21414
dc.subject.classification	Chemistry, Physical	en
dc.subject.other	Acrylamides	en
dc.subject.other	Controlled release	en
dc.subject.other	Controlled release systems	en
dc.subject.other	Coprecipitation method	en
dc.subject.other	Core/shell structure	en
dc.subject.other	Daunorubicin	en
dc.subject.other	Distillation-precipitation polymerization	en
dc.subject.other	Hybrid microspheres	en
dc.subject.other	Hybrid structure	en
dc.subject.other	Magnetic nanoparticles	en
dc.subject.other	Microcontainer	en
dc.subject.other	pH sensitive	en
dc.subject.other	pH value	en
dc.subject.other	Poly(methacrylic acid)	en
dc.subject.other	Release rate	en
dc.subject.other	Structure and properties	en
dc.subject.other	Superparamagnetics	en
dc.subject.other	Trilayers	en
dc.subject.other	Vibrating sample magnetometry	en
dc.subject.other	Acrylic monomers	en
dc.subject.other	Amides	en
dc.subject.other	Distillation	en
dc.subject.other	Dynamic light scattering	en
dc.subject.other	Ethanol	en
dc.subject.other	Fourier transform infrared spectroscopy	en
dc.subject.other	Microspheres	en
dc.subject.other	Nanoparticles	en
dc.subject.other	Polymerization	en
dc.subject.other	Polymers	en
dc.subject.other	Precipitation (chemical)	en
dc.subject.other	Scanning electron microscopy	en
dc.subject.other	Superparamagnetism	en
dc.subject.other	Transmission electron microscopy	en
dc.subject.other	X ray diffraction	en
dc.subject.other	X ray diffraction analysis	en
dc.subject.other	Nanomagnetics	en
dc.subject.other	daunorubicin	en
dc.subject.other	microsphere	en
dc.subject.other	nanoparticle	en
dc.subject.other	polymer	en
dc.subject.other	article	en
dc.subject.other	chemical structure	en
dc.subject.other	chemistry	en
dc.subject.other	magnetism	en
dc.subject.other	particle size	en
dc.subject.other	pH	en
dc.subject.other	surface property	en
dc.subject.other	synthesis	en
dc.subject.other	Daunorubicin	en
dc.subject.other	Hydrogen-Ion Concentration	en
dc.subject.other	Magnetics	en
dc.subject.other	Microspheres	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Nanoparticles	en
dc.subject.other	Particle Size	en
dc.subject.other	Polymers	en
dc.subject.other	Surface Properties	en
dc.title	Sacrificial template-directed fabrication of superparamagnetic polymer microcontainers for pH-activated controlled release of Daunorubicin	en
heal.type	journalArticle	en
heal.identifier.primary	10.1021/la201240h	en
heal.identifier.secondary	http://dx.doi.org/10.1021/la201240h	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	Magnetic pH-sensitive microcontainers were produced by a four-step process. The first step involves the synthesis of citrate-modified magnetic nanoparticles via the coprecipitation method. The second step consists of the encapsulation of magnetic nanoparticles in non-cross-linked poly(methacrylic acid) (PMAA) microspheres through distillation precipitation polymerization, resulting in a core/shell structure. The third step concerns the formation of a poly(N,N′-methylenebis(acrylamide)-co-mathacrylic acid) (P(MBAAm-co-MAA)) layer on the surface of magnetic PMAA microspheres by second distillation precipitation polymerization in order to produce a trilayer hybrid microsphere. The last step deals with the removal of PMAA layer in ethanol and formation of a stable P(MBAAm-co-MAA) microcontainer with magnetic nanoparticles entrapped inside the formed cavity. This process is simple and leads to the formation of superparamagnetic pH-sensitive microcontainers. The structure and properties of the magnetic microcontainers were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS) to determine the functionalities of the hybrid structure. The magnetic pH-sensitive microcontainers were loaded with Daunorubicin and tested with respect to release rate at different pH values in order to evaluate their functionality as controlled release system. © 2011 American Chemical Society.	en
heal.publisher	AMER CHEMICAL SOC	en
heal.journalName	Langmuir	en
dc.identifier.doi	10.1021/la201240h	en
dc.identifier.isi	ISI:000292124000067	en
dc.identifier.volume	27	en
dc.identifier.issue	13	en
dc.identifier.spage	8478	en
dc.identifier.epage	8485	en