Synthesis and characterization of hydrolytically degradable copolyester biomaterials based on glycolic acid, sebacic acid and ethylene glycol

Simitzis, J; Soulis, S; Triantou, D; Zoumpoulakis, L; Zotali, P

dc.contributor.author	Simitzis, J	en
dc.contributor.author	Soulis, S	en
dc.contributor.author	Triantou, D	en
dc.contributor.author	Zoumpoulakis, L	en
dc.contributor.author	Zotali, P	en
dc.date.accessioned	2014-03-01T01:37:12Z
dc.date.available	2014-03-01T01:37:12Z
dc.date.issued	2011	en
dc.identifier.issn	0957-4530	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21480
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Biomedical applications	en
dc.subject.other	Copolyesters	en
dc.subject.other	Crystallinities	en
dc.subject.other	Degree of polymerization	en
dc.subject.other	Diffractograms	en
dc.subject.other	Experimental data	en
dc.subject.other	Four-parameter model	en
dc.subject.other	FT-IR spectrum	en
dc.subject.other	Glycolates	en
dc.subject.other	Glycolic acids	en
dc.subject.other	Homopolyesters	en
dc.subject.other	Hydrolytic degradation	en
dc.subject.other	Maximum types	en
dc.subject.other	Molar feed ratio	en
dc.subject.other	Molar ratio	en
dc.subject.other	Orthorhombic crystal system	en
dc.subject.other	Peak intensity	en
dc.subject.other	Poly(glycolic acid)	en
dc.subject.other	Sebacic acid	en
dc.subject.other	Two-parameter models	en
dc.subject.other	Wave numbers	en
dc.subject.other	XRD	en
dc.subject.other	Biological materials	en
dc.subject.other	Degradation	en
dc.subject.other	Ethylene glycol	en
dc.subject.other	Medical applications	en
dc.subject.other	Organic solvents	en
dc.subject.other	Polymerization	en
dc.subject.other	Ethylene	en
dc.subject.other	ethylene glycol	en
dc.subject.other	poly(ethylene sebacate)	en
dc.subject.other	poly(glycolic acid)	en
dc.subject.other	polyester	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	hydrolysis	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	priority journal	en
dc.subject.other	synthesis	en
dc.subject.other	X ray diffraction	en
dc.title	Synthesis and characterization of hydrolytically degradable copolyester biomaterials based on glycolic acid, sebacic acid and ethylene glycol	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s10856-011-4463-8	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s10856-011-4463-8	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	Copolyesters of glycolic acid (G) combined with sebacic acid (S) and ethylene glycol were synthesized in different molar ratios (G: 0-100% and S: 100-0%) and their hydrolytic degradation was studied and correlated with their structures. Based on the FTIR spectra of the homopolyesters and copolyesters and the normalized peak intensity of the I2918, I2848 and I1087 for the corresponding wavenumbers, it is concluded that the I2918 and the I2848 are in accordance with the mean number degree of polymerization of ethylene sebacate units and the I1087 is in accordance with the mean number degree of polymerization of glycolate units. Based on the XRD diffractograms, poly(ethylene sebacate) and poly(glycolic acid) belong to the monoclinic and the orthorhombic crystal system, respectively and both have higher crystallinity than the copolyesters. The experimental data of the hydrolytic degradation were fitted with exponential rise to maximum type functions using two-parameter model and four-parameter model. Three regions can been distinguished for the hydrolytic degradation by decreasing the molar feed ratio of sebacic acid, which are correlated with the changes of crystallinity. Two copolyesters are proposed: first the copolyester with high amount of glycolate units (S10G90) having higher hydrolytic degradation than G100 and second the copolyester with equal amount of glycolate and ethylene sebacate units (S50G50), having lower hydrolytic degradation than G100. These hydrolytically degradable copolyesters are soluble in common organic solvents, opposite to poly(glycolic acid) and could have perspectives for biomedical applications. © 2011 Springer Science+Business Media, LLC.	en
heal.publisher	SPRINGER	en
heal.journalName	Journal of Materials Science: Materials in Medicine	en
dc.identifier.doi	10.1007/s10856-011-4463-8	en
dc.identifier.isi	ISI:000297621700009	en
dc.identifier.volume	22	en
dc.identifier.issue	12	en
dc.identifier.spage	2673	en
dc.identifier.epage	2684	en