New approach to the synthesis of O-phosphoserine and related peptides

Theodoropoulos, D; Gazopoulos, J; Souchleris, I

dc.contributor.author	Theodoropoulos, D	en
dc.contributor.author	Gazopoulos, J	en
dc.contributor.author	Souchleris, I	en
dc.date.accessioned	2014-03-01T01:37:38Z
dc.date.available	2014-03-01T01:37:38Z
dc.date.issued	1960	en
dc.identifier.issn	00280836	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/21583
dc.title	New approach to the synthesis of O-phosphoserine and related peptides	en
heal.type	journalArticle	en
heal.identifier.primary	10.1038/185606b0	en
heal.identifier.secondary	http://dx.doi.org/10.1038/185606b0	en
heal.publicationDate	1960	en
heal.abstract	A General method of synthesizing phosphorylated amino-hydroxy acids and derived peptides, using diphenylphosphorylchloridate as the phosphorylating agent, was introduced by Riley et al.1. This method has been applied with rather satisfactory results in the synthesis of α-carbethoxy-L-lysyl- L-(O-phosphoryl)-serylglycine2; but further studies on the inhibitory spectrum of phosphoserine3 towards proteolytic enzymes, and the effect of phosphatases2 upon various substrates as well, stress the necessity of alternate synthetic methods. © 1960 Nature Publishing Group.	en
heal.journalName	Nature	en
dc.identifier.doi	10.1038/185606b0	en
dc.identifier.volume	185	en
dc.identifier.issue	4713	en
dc.identifier.spage	606	en
dc.identifier.epage	607	en