Shear-Induced Platelet Aggregation Can Be Mediated by vWF Released From Platelets, as Well as by Exogenous Large or Unusually Large vWF Multimers, Requires Adenosine Diphosphate, and Is Resistant to Aspirin

Moake, J; Turner, N; Stathopoulos, N; Nolasco, L; Hellums, J

dc.contributor.author	Moake, J	en
dc.contributor.author	Turner, N	en
dc.contributor.author	Stathopoulos, N	en
dc.contributor.author	Nolasco, L	en
dc.contributor.author	Hellums, J	en
dc.date.accessioned	2014-03-01T01:39:22Z
dc.date.available	2014-03-01T01:39:22Z
dc.date.issued	1988	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/22729
dc.relation.uri	http://bloodjournal.hematologylibrary.org/cgi/reprint/71/5/1366.pdf	en
dc.subject	Blood Cells	en
dc.subject	Cell Membrane	en
dc.subject	Platelet Aggregation	en
dc.subject	Adenosine Diphosphate	en
dc.subject	Fluid Shear Stress	en
dc.subject	Shear Stress	en
dc.subject	von willebrand factor	en
dc.title	Shear-Induced Platelet Aggregation Can Be Mediated by vWF Released From Platelets, as Well as by Exogenous Large or Unusually Large vWF Multimers, Requires Adenosine Diphosphate, and Is Resistant to Aspirin	en
heal.type	journalArticle	en
heal.publicationDate	1988	en
heal.abstract	Fluid shear stress in arteries and arterioles partially obstructed by atherosclerosis or spasm may exceed the normal time-average level of 20 dyne/cm2. In vitro. at fluid shear stresses of 30 to 60 dyne/cm2 applied for 30 seconds. platelet aggregation occurs. At these shear stresses. either large or unusually large von Willebrand factor (vWF) multimers in the suspending fluid exogenous to	en