trans-ternary complexes of Pd(II) with nucleosides and dipeptides. Models for trans-DDP-DNA-protein crosslinks

Kasselouri, S; Laussac, J-P; Hadjiliadis, N

dc.contributor.author	Kasselouri, S	en
dc.contributor.author	Laussac, J-P	en
dc.contributor.author	Hadjiliadis, N	en
dc.date.accessioned	2014-03-01T01:39:40Z
dc.date.available	2014-03-01T01:39:40Z
dc.date.issued	1989	en
dc.identifier.issn	00201693	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/22917
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0004827650&partnerID=40&md5=4093440839a5873a75cf5f014f724d53	en
dc.title	trans-ternary complexes of Pd(II) with nucleosides and dipeptides. Models for trans-DDP-DNA-protein crosslinks	en
heal.type	journalArticle	en
heal.publicationDate	1989	en
heal.abstract	The reactions of complexes of the type trans-[Pd(dipeptide)2Cl2] with the nucleosides guo and ino in aqueous solutions, produce the ternary complexes trans-[Pd(dipeptide)2(nucl)2]Cl2, which were isolated and characterized as solid adducts, with elemental analysis, conductivity measurements, IR and 1H NMR spectra. Many isomers, corresponding to the head to head, head to tail and tail to tail orientations of the nucleosides, with two major ones called 'closed' and 'opened' forms, are observed with 1H NMR in D2O solutions, for the complexes. The ratio of the two major isomers being 1:1.5 in D2O solutions of the 'opened' to 'losed' form, favors the 'opened' form in DMSO-d6 solutions changing from 1:6 to 1:10 for the guo derivatives, while this form is the only one observed in the ino derivatives. Possible ligand-ligand interactions are detected in the 1H NMR spectra of the compounds. The anti conformation of the sugar moiety of guo is found to increase in the trans-ternary complexes of the present system and with the presence of the dipeptide, indicating that the model DNA-Pt-protein crosslink may be responsible for the toxicity of platinum drugs. © 1989.	en
heal.journalName	Inorganica Chimica Acta	en
dc.identifier.volume	166	en
dc.identifier.issue	2	en
dc.identifier.spage	239	en
dc.identifier.epage	248	en