Magnesium perchlorate and cis-platinum as radiosensitizers in in vitro radiolysis of nucleotides.

Anastassopoulou, JD

dc.contributor.author	Anastassopoulou, JD	en
dc.date.accessioned	2014-03-01T01:39:59Z
dc.date.available	2014-03-01T01:39:59Z
dc.date.issued	1990	en
dc.identifier.issn	09531424	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/23045
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0025395199&partnerID=40&md5=5c5a68cc057878ffd0f7ab328fcaa756	en
dc.subject.other	cisplatin	en
dc.subject.other	guanine nucleotide	en
dc.subject.other	guanosine phosphate	en
dc.subject.other	hydroxide	en
dc.subject.other	hydroxyl radical	en
dc.subject.other	magnesium	en
dc.subject.other	magnesium perchlorate	en
dc.subject.other	perchloric acid	en
dc.subject.other	water	en
dc.subject.other	article	en
dc.subject.other	chemical structure	en
dc.subject.other	gamma radiation	en
dc.subject.other	high performance liquid chromatography	en
dc.subject.other	radiation exposure	en
dc.subject.other	solution and solubility	en
dc.subject.other	spectrophotometry	en
dc.subject.other	5'-Guanylic Acid	en
dc.subject.other	Chromatography, High Pressure Liquid	en
dc.subject.other	Cisplatin	en
dc.subject.other	Gamma Rays	en
dc.subject.other	Guanine Nucleotides	en
dc.subject.other	Hydroxides	en
dc.subject.other	Hydroxyl Radical	en
dc.subject.other	Magnesium	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Perchloric Acid	en
dc.subject.other	Solutions	en
dc.subject.other	Spectrophotometry	en
dc.subject.other	Water	en
dc.title	Magnesium perchlorate and cis-platinum as radiosensitizers in in vitro radiolysis of nucleotides.	en
heal.type	journalArticle	en
heal.publicationDate	1990	en
heal.abstract	The mechanism of the gamma-radiolysis of the nucleotide guanosine-5'-monophosphate (5'-GMP) in the presence of Mg++ ions and cis-platinum was investigated. From high performance liquid chromatography and spectroscopy studies it was found that the OH radicals, produced in irradiated aqueous solutions, reacted with 5'-GMP by addition to the double bonds and that Mg++ as well as cis-Pt sensitized the nucleotide to radiation damage. Furthermore, an important finding was the fact that when the irradiation took place in aerated solutions, the Mg++ ions, contrary to cis-Pt, did not seem to have any effect on the decomposition yield G(-5'-GMP). This result together with the sensitization (100% increase) observed in deaerated solutions led to the conclusion that irradiation in the presence of Mg++ may result in a more effective gamma-radiation therapy for tumours.	en
heal.journalName	Magnesium research : official organ of the International Society for the Development of Research on Magnesium	en
dc.identifier.volume	3	en
dc.identifier.issue	1	en
dc.identifier.spage	19	en
dc.identifier.epage	21	en