Role of magnesium as radiosensitizer in the in vitro radiolysis of aqueous solutions of guanosine-5'-monophosphate disodium.

Anastassopoulou, JD; Brekoulakis, J; Missailidis, S

dc.contributor.author	Anastassopoulou, JD	en
dc.contributor.author	Brekoulakis, J	en
dc.contributor.author	Missailidis, S	en
dc.date.accessioned	2014-03-01T01:41:54Z
dc.date.available	2014-03-01T01:41:54Z
dc.date.issued	1993	en
dc.identifier.issn	09531424	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/23670
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0027605714&partnerID=40&md5=ca8fe447ac6459451f76d86aea6d481f	en
dc.subject.other	cyclic GMP	en
dc.subject.other	magnesium derivative	en
dc.subject.other	Radiation Sensitizing Agents	en
dc.subject.other	radiosensitizing agent	en
dc.subject.other	article	en
dc.subject.other	chemistry	en
dc.subject.other	fast atom bombardment mass spectrometry	en
dc.subject.other	gamma radiation	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	radiation exposure	en
dc.subject.other	radiochemistry	en
dc.subject.other	solution and solubility	en
dc.subject.other	ultraviolet spectrophotometry	en
dc.subject.other	Cyclic GMP	en
dc.subject.other	Gamma Rays	en
dc.subject.other	Magnesium Compounds	en
dc.subject.other	Radiation-Sensitizing Agents	en
dc.subject.other	Radiochemistry	en
dc.subject.other	Solutions	en
dc.subject.other	Spectrometry, Mass, Fast Atom Bombardment	en
dc.subject.other	Spectrophotometry, Ultraviolet	en
dc.subject.other	Spectroscopy, Fourier Transform Infrared	en
dc.title	Role of magnesium as radiosensitizer in the in vitro radiolysis of aqueous solutions of guanosine-5'-monophosphate disodium.	en
heal.type	journalArticle	en
heal.publicationDate	1993	en
heal.abstract	A combination of Fourier Transform Infrared (FT-IR) spectroscopy and mass spectrometry (MS) was used to investigate the role of Mg2+ ions in gamma-radiolysis of aqueous solutions of guanosine-5'-monophosphate disodium salt. The FT-IR intensity changes together with the mass spectra suggest the interaction of the magnesium atom with the base guanine at the N7 site. The decomposition-limiting yield G(-5'-GMPNa2) in deaerated as well as in nitrous oxide saturated solutions, determined by measuring the absorbance at 253 nm, was found to be 0.6 and 1.2 respectively. Comparison of these values with the corresponding limiting yields of 0.3 and 0.6 that were found in the absence of Mg2+ ions shows the sensitizing role of this ion in the radiolysis of the mononucleotide. This in vitro behaviour may result in more effective local therapy of tumour by gamma-ray irradiation in the presence of Mg2+, due to the 100 per cent sensitization of the radiolysis reaction. It remains to be seen whether this is also true in vivo.	en
heal.journalName	Magnesium research : official organ of the International Society for the Development of Research on Magnesium	en
dc.identifier.volume	6	en
dc.identifier.issue	2	en
dc.identifier.spage	113	en
dc.identifier.epage	119	en