Plasticization of biodegradable polymers for use in controlled release

Andreopoulos, AG

dc.contributor.author	Andreopoulos, AG	en
dc.date.accessioned	2014-03-01T01:42:41Z
dc.date.available	2014-03-01T01:42:41Z
dc.date.issued	1994	en
dc.identifier.issn	02676605	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/23892
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0028212935&partnerID=40&md5=e5dda3da7199d43fd0c285d4691314ec	en
dc.subject.other	Biodegradation	en
dc.subject.other	Concentration (process)	en
dc.subject.other	Controlled drug delivery	en
dc.subject.other	Copolymers	en
dc.subject.other	Drug dosage	en
dc.subject.other	Drug therapy	en
dc.subject.other	Glycerol	en
dc.subject.other	Mixtures	en
dc.subject.other	Molecular weight	en
dc.subject.other	Oligomers	en
dc.subject.other	Plasticizers	en
dc.subject.other	Biodegradable polymers	en
dc.subject.other	Controlled released system	en
dc.subject.other	Plasticization	en
dc.subject.other	Polylactic acid	en
dc.subject.other	Salicylic acid	en
dc.subject.other	Organic polymers	en
dc.subject.other	glycerol	en
dc.subject.other	oligomer	en
dc.subject.other	plasticizer	en
dc.subject.other	polymer	en
dc.subject.other	propylene glycol	en
dc.subject.other	salicylic acid	en
dc.subject.other	article	en
dc.subject.other	biodegradation	en
dc.subject.other	drug release	en
dc.subject.other	priority journal	en
dc.subject.other	sustained release preparation	en
dc.subject.other	temperature	en
dc.subject.other	Biodegradation	en
dc.subject.other	Drug Delivery Systems	en
dc.subject.other	Human	en
dc.subject.other	Lactates	en
dc.subject.other	Materials Testing	en
dc.subject.other	Plasticizers	en
dc.subject.other	Polymers	en
dc.subject.other	Propylene Glycols	en
dc.subject.other	Salicylic Acids	en
dc.title	Plasticization of biodegradable polymers for use in controlled release	en
heal.type	journalArticle	en
heal.publicationDate	1994	en
heal.abstract	The design of a plasticized, biodegradable polymeric material, suitable for application as a controlled-release system, was attempted. A poly(DL-lactic acid) oligomer was plasticized with 1,2-propylene glycol and glycerol. The latter plasticizer showed poor compatibility whereas 1,2-propylene glycol was compatible with the polymer up to high concentrations. The mixtures prepared displayed considerable depression of processing temperature and enhanced delivery of salicylic acid, in the early stages of release. It seemed, therefore, feasible to produce systems which allow easy and safe processing and can be injected into a body cavity, without the need for surgical retrieval after completion of the release. Furthermore, the differential rate of drug delivery might be of profound interest for cases where elevated drug doses are necessary in the beginning of treatment.The design of a plasticized, biodegradable polymeric material, suitable for application as a controlled-release system, was attempted. A poly(DL-lactic acid) oligomer was plasticized with 1,2-propylene glycol and glycerol. The latter plasticizer showed poor compatibility whereas 1,2-propylene glycol was compatible with the polymer up to high concentrations. The mixtures prepared displayed considerable depression of processing temperature and enhanced delivery of salicylic acid, in the early stages of release. It seemed, therefore, feasible to produce systems which allow easy and safe processing and can be injected into a body cavity, without the need for surgical retrieval after completion of the release. Furthermore, the differential rate of drug delivery might be of profound interest for cases where elevated drug doses are necessary in the beginning of treatment.	en
heal.publisher	Publ by Elsevier Science Publ Ltd, Barking, United Kingdom	en
heal.journalName	Clinical Materials	en
dc.identifier.volume	15	en
dc.identifier.issue	2	en
dc.identifier.spage	89	en
dc.identifier.epage	92	en