AUTOIMMUNE EPITHELIITIS - SJOGRENS-SYNDROME

SKOPOULI, FN; MOUTSOPOULOS, HM

dc.contributor.author	SKOPOULI, FN	en
dc.contributor.author	MOUTSOPOULOS, HM	en
dc.date.accessioned	2014-03-01T01:42:46Z
dc.date.available	2014-03-01T01:42:46Z
dc.date.issued	1994	en
dc.identifier.issn	0392-856X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/23930
dc.subject	SJOGRENS SYNDROME	en
dc.subject	AUTOIMMUNE	en
dc.subject	EPITHELIAL CELLS	en
dc.subject	MINOR SALIVARY GLANDS	en
dc.subject	LIVER INVOLVEMENT	en
dc.subject	LUNG INVOLVEMENT	en
dc.subject	INTERSTITIAL NEPHRITIS	en
dc.subject.classification	Rheumatology	en
dc.title	AUTOIMMUNE EPITHELIITIS - SJOGRENS-SYNDROME	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1994	en
heal.abstract	Sjogren's syndrome (SS), an autoimmune exocrinopathy, is a common, chronic disease of females. Clinical studies of kidney involvement in SS patients have shown that the predominant lesion is interstitial nephritis which produces tubular dysfunction. Studies on lung involvement have previously indicated that one fourth of SS patients suffer from subclinical interstitial lung disease. Re-evalution, however, of the pulmonary disease using functional, radiologic and histopathologic studies showed that the lesion starts peribronchially. Finally evaluation of liver disease in SS patients revealed that this consists of a pericholangeal round-cell infiltrate resembling the early lesion of primary biliary cirrhosis. These clinical studies suggest that the systemic manifestations of SS are probably due to the attraction of lymphocytes by different epithelial tissues. Studies of the epithelial cells of minor salivary glands from SS patients have shown that these inappropriately and selectively express HLA class II molecules and the proto-oncogene c-myc. Evaluation of cytokines in the minor salivary glands from these patients by in situ hybridization revealed that the proinflammatory cytokines IL-I and IL-6 are also produced by the epithelial cells. Finally, proviral DNA has been shown to be incorporated in the DNA of epithelial cells. On the basis of these clinical and laboratory observations, we would like to suggest that the target tissue involved in the autoimmune histopathologic lesions of SS is the epithelium, and therefore we propose the term ''Autoimmune Epitheliitis'' instead of ''Sjogren's syndrome'' for this disease.	en
heal.publisher	CLINICAL & EXPER RHEUMATOLOGY	en
heal.journalName	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY	en
dc.identifier.isi	ISI:A1994QN12300004	en
dc.identifier.volume	12	en
dc.identifier.spage	S9	en
dc.identifier.epage	S11	en