Acylaminoacetyl derivatives of active methylene compounds. 4 [1]. Synthesis of N-protected tetramic acids via the C-acylation reaction of meldrum's acid with the imidazolides of N-protected glycines

Hamilakis, S; Kontonassios, D; Sandris, C

dc.contributor.author	Hamilakis, S	en
dc.contributor.author	Kontonassios, D	en
dc.contributor.author	Sandris, C	en
dc.date.accessioned	2014-03-01T01:44:38Z
dc.date.available	2014-03-01T01:44:38Z
dc.date.issued	1996	en
dc.identifier.issn	0022152X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24438
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0029738895&partnerID=40&md5=dddfe68e3a703309ebf31e0b5c59b379	en
dc.subject.other	tetramic acid derivative	en
dc.subject.other	article	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	nuclear magnetic resonance	en
dc.subject.other	reaction analysis	en
dc.title	Acylaminoacetyl derivatives of active methylene compounds. 4 [1]. Synthesis of N-protected tetramic acids via the C-acylation reaction of meldrum's acid with the imidazolides of N-protected glycines	en
heal.type	journalArticle	en
heal.publicationDate	1996	en
heal.abstract	Meldrum's acid has been found to be effectively acylated using the imidazolides of N-protected glycines, X-NHCH2COOH (X = -COPh, -COMe, -Z, -Boc, -COOMe and -COOEt). The corresponding C-acylation compounds were isolated in high yields and were readily converted to the N-protected tetramic acids. It was shown by pmr spectroscopy that these acids exist as the enol tautomers in DMSO-d6 solution, whereas in deuteriochloroform solution both the enol and keto tautomers can be observed.	en
heal.journalName	Journal of Heterocyclic Chemistry	en
dc.identifier.volume	33	en
dc.identifier.issue	3	en
dc.identifier.spage	825	en
dc.identifier.epage	829	en