Treatment of acute biliary tract infections with ofloxacin: A randomized, controlled clinical trial

Karachalios, GN; Nasiopoulou, DD; Bourlinou, PK; Reppa, A

dc.contributor.author	Karachalios, GN	en
dc.contributor.author	Nasiopoulou, DD	en
dc.contributor.author	Bourlinou, PK	en
dc.contributor.author	Reppa, A	en
dc.date.accessioned	2014-03-01T01:44:56Z
dc.date.available	2014-03-01T01:44:56Z
dc.date.issued	1996	en
dc.identifier.issn	09461965	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24523
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0030450970&partnerID=40&md5=911276f7d9a89ff34e5c998ed77b5090	en
dc.subject	Cholangitis	en
dc.subject	Cholecystitis	en
dc.subject	Ofloxacin	en
dc.subject.other	ceftriaxone	en
dc.subject.other	ofloxacin	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	biliary tract infection	en
dc.subject.other	cholangitis	en
dc.subject.other	cholecystitis	en
dc.subject.other	clinical trial	en
dc.subject.other	controlled clinical trial	en
dc.subject.other	controlled study	en
dc.subject.other	diarrhea	en
dc.subject.other	drug efficacy	en
dc.subject.other	human	en
dc.subject.other	intravenous drug administration	en
dc.subject.other	major clinical study	en
dc.subject.other	oral drug administration	en
dc.subject.other	phlebitis	en
dc.subject.other	randomized controlled trial	en
dc.subject.other	rash	en
dc.subject.other	Anti-Infective Agents	en
dc.subject.other	Bacteremia	en
dc.subject.other	Ceftriaxone	en
dc.subject.other	Cephalosporins	en
dc.subject.other	Cholangitis	en
dc.subject.other	Cholecystitis	en
dc.subject.other	Escherichia coli Infections	en
dc.subject.other	Female	en
dc.subject.other	Gram-Negative Bacterial Infections	en
dc.subject.other	Humans	en
dc.subject.other	Klebsiella Infections	en
dc.subject.other	Klebsiella pneumoniae	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Ofloxacin	en
dc.subject.other	Phlebitis	en
dc.title	Treatment of acute biliary tract infections with ofloxacin: A randomized, controlled clinical trial	en
heal.type	journalArticle	en
heal.publicationDate	1996	en
heal.abstract	The combination of penicillin with an aminoglycoside has been recommended as an initial treatment of choice for patients with acute infections of the biliary tract. However, many patients have incidence of renal problems and for this reason aminoglycosides must be avoided. Newer antimicrobial agents with lesser nephrotoxic effects will be tried. We, therefore, performed a prospective, randomized trial of ofloxacin, a new quinolone and ceftriaxone in patients with acute biliary tract infections. Fifty-two patients with severe biliary tract infections (cholecystitis and cholangitis) were randomly assigned to receive either ofloxacin (n = 28) or ceftriaxone (n = 24). The 2 groups receiving antibiotics were similar with respect to all clinical and laboratory parameters. Bacteria were documented in 48% of patients in the ofloxacin group and in 46% in the ceftriaxone group. The percentage of patients with a clinical cure or significant improvement was the same in the 2 groups. No significant difference was noted between the 2 treatment groups with respect to drug toxicity. These data suggest that intravenous ofloxacin followed by oral administration is an effective and safe single drug for the therapy of patients with acute biliary tract infections.	en
heal.journalName	International Journal of Clinical Pharmacology and Therapeutics	en
dc.identifier.volume	34	en
dc.identifier.issue	12	en
dc.identifier.spage	555	en
dc.identifier.epage	557	en