Acylaminoacetyl derivatives of active methylene compounds .4. Synthesis of N-protected tetramic acids via the C-acylation reaction of Meldrum's acid with the imidazolides of N-protected glycines

Hamilakis, S; Kontonassios, D; Sandris, C

dc.contributor.author	Hamilakis, S	en
dc.contributor.author	Kontonassios, D	en
dc.contributor.author	Sandris, C	en
dc.date.accessioned	2014-03-01T01:44:59Z
dc.date.available	2014-03-01T01:44:59Z
dc.date.issued	1996	en
dc.identifier.issn	0022-152X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24534
dc.subject.classification	Chemistry, Organic	en
dc.title	Acylaminoacetyl derivatives of active methylene compounds .4. Synthesis of N-protected tetramic acids via the C-acylation reaction of Meldrum's acid with the imidazolides of N-protected glycines	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1996	en
heal.abstract	Meldrum's acid has been found to be effectively acylated using the imidazolides of N-protected glycines, X-NHCH2COOH (X = -COPh, -COMe, -Z, -Boc, -COOMe and -COOEt). The corresponding C-acylation compounds were isolated in high yields and were readily converted to the N-protected tetramic acids. It was shown by pmr spectroscopy that these acids exist as the enol tautomers in DMSO-d(6) solution, whereas in deuteriochloroform solution both the enol and keto tautomers can be observed.	en
heal.publisher	HETERO CORPORATION	en
heal.journalName	JOURNAL OF HETEROCYCLIC CHEMISTRY	en
dc.identifier.isi	ISI:A1996VC21600048	en
dc.identifier.volume	33	en
dc.identifier.issue	3	en
dc.identifier.spage	825	en
dc.identifier.epage	829	en