Variable antifungal susceptibility of wild-type Candida albicans phenotypes from neutropenic hosts

Velegraki, A; Papalambrou, D; Soremi, S; Legakis, NJ

dc.contributor.author	Velegraki, A	en
dc.contributor.author	Papalambrou, D	en
dc.contributor.author	Soremi, S	en
dc.contributor.author	Legakis, NJ	en
dc.date.accessioned	2014-03-01T01:45:28Z
dc.date.available	2014-03-01T01:45:28Z
dc.date.issued	1996	en
dc.identifier.issn	0934-9723	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24588
dc.subject.classification	Infectious Diseases	en
dc.subject.classification	Microbiology	en
dc.subject.other	WHITE-OPAQUE TRANSITION	en
dc.subject.other	MORPHOLOGICAL MUTANTS	en
dc.subject.other	FLUCONAZOLE	en
dc.subject.other	KARYOTYPE	en
dc.subject.other	YEAST	en
dc.title	Variable antifungal susceptibility of wild-type Candida albicans phenotypes from neutropenic hosts	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1996	en
heal.abstract	The aim of the present study was to investigate the relationship between phenotypes of Candida albicans strains isolated from clinical specimens and susceptibility of the strains to two antifungal agents, itraconazole and fluconazole, Oropharyngeal, gastrointestinal tract, and urogenital tract specimens were collected from 131 neutropenic patients with Candida infection who had received no previous prophylactic treatment. The most frequent species isolated was Candida albicans, followed by Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsilosis. Each of the 44 Candida albicans strains recovered was found to express one of four phenotypes: smooth, irregular, fuzzy or stipple. Mean minimum inhibitory concentrations (MICs) of itraconazole and fluconazole as determined by the microdilution method and the E-test were consistently higher for Candida albicans strains expressing the stipple phenotype, The mean MICs for the four phenotypes of the Candida albicans strains ranged between 0.35 mu g/ml and 2.41 mu g/ml for itraconazole and 2.78 mu g/ml and 5.2 mu g/ml for fluconazole, Antifungal susceptibility of the stipple phenotype requires careful appraisal, especially in patients clinically unresponsive to azole chemotherapy or in cases of life-threatening, deep-seated Candida infections.	en
heal.publisher	MMW MEDIZIN VERLAG GMBH	en
heal.journalName	EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES	en
dc.identifier.isi	ISI:A1996VY86000002	en
dc.identifier.volume	15	en
dc.identifier.issue	11	en
dc.identifier.spage	854	en
dc.identifier.epage	860	en