Detection of 'PNH red cell' populations in hematological disorders using the Sephacryl Gel Test micro typing system

Meletis, J; Michali, E; Samarkos, M; Konstantopoulos, K; Meletis, C; Terpos, E; Tsimberidou, A; Chandrinou, E; Viniou, N; Rombos, Y; Pangalis, GA; Yataganas, X; Loukopoulos, D

dc.contributor.author	Meletis, J	en
dc.contributor.author	Michali, E	en
dc.contributor.author	Samarkos, M	en
dc.contributor.author	Konstantopoulos, K	en
dc.contributor.author	Meletis, C	en
dc.contributor.author	Terpos, E	en
dc.contributor.author	Tsimberidou, A	en
dc.contributor.author	Chandrinou, E	en
dc.contributor.author	Viniou, N	en
dc.contributor.author	Rombos, Y	en
dc.contributor.author	Pangalis, GA	en
dc.contributor.author	Yataganas, X	en
dc.contributor.author	Loukopoulos, D	en
dc.date.accessioned	2014-03-01T01:45:55Z
dc.date.available	2014-03-01T01:45:55Z
dc.date.issued	1997	en
dc.identifier.issn	10428194	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24794
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-6844258194&partnerID=40&md5=eb53f61d357a338f1ebba1f6cde58712	en
dc.subject	Aplastic anemia	en
dc.subject	CD55 (DAF)	en
dc.subject	CD59 (MIRL)	en
dc.subject	GPI-anchor proteins	en
dc.subject	Myelodysplastic syndromes	en
dc.subject	Paroxysmal nocturnal hemoglobinuria	en
dc.subject.other	cd59 antigen	en
dc.subject.other	decay accelerating factor	en
dc.subject.other	article	en
dc.subject.other	clinical trial	en
dc.subject.other	controlled study	en
dc.subject.other	diagnostic test	en
dc.subject.other	erythrocyte	en
dc.subject.other	hematologic disease	en
dc.subject.other	human	en
dc.subject.other	human cell	en
dc.subject.other	major clinical study	en
dc.subject.other	paroxysmal nocturnal hemoglobinuria	en
dc.subject.other	priority journal	en
dc.subject.other	Antigens, CD55	en
dc.subject.other	Antigens, CD59	en
dc.subject.other	Erythrocytes	en
dc.subject.other	Hematologic Diseases	en
dc.subject.other	Hemoglobinuria, Paroxysmal	en
dc.subject.other	Humans	en
dc.subject.other	Immunophenotyping	en
dc.title	Detection of 'PNH red cell' populations in hematological disorders using the Sephacryl Gel Test micro typing system	en
heal.type	journalArticle	en
heal.publicationDate	1997	en
heal.abstract	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder characterised by an unusual sensitivity of abnormal red cell population(s) to complement lysis, due to a complete or incomplete defect of various surface molecules, including CD55 and CD59. PNH has been associated with various hematological disorders. Using a newly introduced method, the Sephacryl gel test microtyping system, we investigated the presence of CD55 or CD59 defective red cell populations in several hematological disorders. It was also found that a large proportion of such patients possess CD55 deficient populations, while a smaller but still significant proportion possess CD59 deficient populations. Defective red cell populations were detected in normal subjects as well. These findings need further investigation. Nevertheless the Sephacryl Gel Test microtyping system although non specific, seems to be useful in screening for the PNH and/or 'PNH-like' red cell defect in several hematological disorders.	en
heal.journalName	Leukemia and Lymphoma	en
dc.identifier.volume	28	en
dc.identifier.issue	1-2	en
dc.identifier.spage	177	en
dc.identifier.epage	182	en