Findings of computerised nuclear morphometry of papillary thyroid carcinoma in correlation with known prognostic factors

Tseleni, S; Kavantzas, N; Yova, D; Alexandratou, E; Karydakis, V; Gogas, J; Davaris, P

dc.contributor.author	Tseleni, S	en
dc.contributor.author	Kavantzas, N	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Alexandratou, E	en
dc.contributor.author	Karydakis, V	en
dc.contributor.author	Gogas, J	en
dc.contributor.author	Davaris, P	en
dc.date.accessioned	2014-03-01T01:45:56Z
dc.date.available	2014-03-01T01:45:56Z
dc.date.issued	1997	en
dc.identifier.issn	03929078	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24801
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0031404597&partnerID=40&md5=34e2dd8c4f793047450431fcf5524938	en
dc.subject	Image analysis	en
dc.subject	Nuclear morphometry	en
dc.subject	Papillary thyroid carcinoma	en
dc.subject	Prognostic factors	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	cancer invasion	en
dc.subject.other	cancer size	en
dc.subject.other	clinical article	en
dc.subject.other	female	en
dc.subject.other	histopathology	en
dc.subject.other	human	en
dc.subject.other	human tissue	en
dc.subject.other	image analysis	en
dc.subject.other	male	en
dc.subject.other	priority journal	en
dc.subject.other	prognosis	en
dc.subject.other	thyroid carcinoma	en
dc.subject.other	thyroid papillary carcinoma	en
dc.subject.other	Adult	en
dc.subject.other	Age Factors	en
dc.subject.other	Aged	en
dc.subject.other	Carcinoma, Papillary	en
dc.subject.other	Cell Nucleus	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Image Interpretation, Computer-Assisted	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Prognosis	en
dc.subject.other	Thyroid Neoplasms	en
dc.title	Findings of computerised nuclear morphometry of papillary thyroid carcinoma in correlation with known prognostic factors	en
heal.type	journalArticle	en
heal.publicationDate	1997	en
heal.abstract	The aim of this study was the evaluation of the usefulness of nuclear morphometry in the pathology of papillary thyroid carcinoma by computer- aided image analysis and the statistical comparison of nuclear morphometric parameters with age of patients, tumor size and the presence or not of thyroid capsule invasion. Thirty three cases of papillary thyroid carcinoma were classified in two groups according to patients' age (group I:<45 years and group II:>45 years), according to tumor's size (group I: <2.5 cm, group II:>2.5 cm) and to the presence or not of thyroid capsule invasion (group I: invasion (+), group II: no invasion (-)). The following six nuclear morphometric parameters were measured in a large number of randomly selected nuclei of each case: area, perimeter, major axis length, minor axis length, elongation and roundness. The statistical analysis was performed using special algorithms and the results of the two groups of each prognostic factor examined, were compared for each of the measured parameter using the t-test. When the classification was associated with age it was shown that younger people (group I) have lower area, perimeter, major axis length, elongation and roundness means of papillary thyroid carcinoma nuclei than older ones (group II) whereas minor axis length did not show any difference between the two groups. When the classification was associated with tumor size it was shown that younger people (group I) have lower area, perimeter, major axis length means of papillary thyroid carcinoma nuclei than older ones (group II) whereas minor axis length, elongation and roundness did not show any difference between the two groups. Finally, when the cases were classified according to the presence or not of the capsule invasion it was shown that younger people (group I) have lower area, perimeter, major axis length means of papillary thyroid carcinoma nuclei than older ones (group II) whereas roundness did not showed any difference between the two groups. On the other hand younger people (group I) have higher elongation and roundness means than the older ones (group II). Nuclear morphometry in association with the patients' follow-up could represent an important prognostic index for papillary thyroid carcinoma.	en
heal.journalName	Journal of Experimental and Clinical Cancer Research	en
dc.identifier.volume	16	en
dc.identifier.issue	4	en
dc.identifier.spage	401	en
dc.identifier.epage	406	en