Ketoprofen versus paracetamol in the treatment of acute migraine

Karabetsos, A; Karachalios, G; Bourlinou, P; Reppa, A; Koutri, R; Fotiadou, A

dc.contributor.author	Karabetsos, A	en
dc.contributor.author	Karachalios, G	en
dc.contributor.author	Bourlinou, P	en
dc.contributor.author	Reppa, A	en
dc.contributor.author	Koutri, R	en
dc.contributor.author	Fotiadou, A	en
dc.date.accessioned	2014-03-01T01:45:57Z
dc.date.available	2014-03-01T01:45:57Z
dc.date.issued	1997	en
dc.identifier.issn	00178748	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24814
dc.subject	acute migraine	en
dc.subject	ketoprofen	en
dc.subject	paracetamol	en
dc.subject.other	ketoprofen	en
dc.subject.other	nonsteroid antiinflammatory agent	en
dc.subject.other	paracetamol	en
dc.subject.other	prostaglandin synthase inhibitor	en
dc.subject.other	adult	en
dc.subject.other	analgesia	en
dc.subject.other	article	en
dc.subject.other	clinical feature	en
dc.subject.other	clinical trial	en
dc.subject.other	controlled clinical trial	en
dc.subject.other	controlled study	en
dc.subject.other	crossover procedure	en
dc.subject.other	disease severity	en
dc.subject.other	double blind procedure	en
dc.subject.other	drug efficacy	en
dc.subject.other	drug safety	en
dc.subject.other	erythema	en
dc.subject.other	family history	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	intramuscular drug administration	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	migraine	en
dc.subject.other	pain assessment	en
dc.subject.other	priority journal	en
dc.subject.other	randomized controlled trial	en
dc.subject.other	tachycardia	en
dc.subject.other	Acetaminophen	en
dc.subject.other	Acute Disease	en
dc.subject.other	Adult	en
dc.subject.other	Analgesics, Non-Narcotic	en
dc.subject.other	Anti-Inflammatory Agents, Non-Steroidal	en
dc.subject.other	Double-Blind Method	en
dc.subject.other	Humans	en
dc.subject.other	Injections, Intramuscular	en
dc.subject.other	Ketoprofen	en
dc.subject.other	Migraine Disorders	en
dc.title	Ketoprofen versus paracetamol in the treatment of acute migraine	en
heal.type	journalArticle	en
heal.identifier.primary	10.1046/j.1526-4610.1997.3701012.x	en
heal.identifier.secondary	http://dx.doi.org/10.1046/j.1526-4610.1997.3701012.x	en
heal.publicationDate	1997	en
heal.abstract	The efficacy and safety of ketoprofen and paracetamol were compared for the treatment of acute migraine in a randomized, double-blind study of 64 patients. Thirty-four patients received ketoprofen 100 mg intramuscularly, and 30 patients received paracetamol 500 mg intramuscularly. Partial or complete relief of pain and other symptoms was achieved 15 to 20 minutes after administration in the ketoprofen group and within 35 minutes in the paracetamol group. Complete relief of pain was achieved within 30 to 40 minutes after ketoprofen in 28 patients (82.5%) compared to 5 patients (17.5%) in the paracetamol group. Six of the patients treated with ketoprofen needed a second dose for complete relief of pain during the 4-hour follow-up period. Side effects were rare and minimal. Our findings suggest that ketoprofen produced statistically significant benefit in the treatment of acute migraine.	en
heal.journalName	Headache	en
dc.identifier.doi	10.1046/j.1526-4610.1997.3701012.x	en
dc.identifier.volume	37	en
dc.identifier.issue	1	en
dc.identifier.spage	12	en
dc.identifier.epage	14	en