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Daily variation in circulating cytokines and acute-phase proteins correlates with clinical and laboratory indices in community-acquired pneumonia

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dc.contributor.author Kosmas, EN en
dc.contributor.author Baxevanis, CN en
dc.contributor.author Papamichail, M en
dc.contributor.author Kordossis, T en
dc.date.accessioned 2014-03-01T01:46:24Z
dc.date.available 2014-03-01T01:46:24Z
dc.date.issued 1997 en
dc.identifier.issn 0014-2972 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/24900
dc.subject acute-phase proteins en
dc.subject community-acquired pneumonia en
dc.subject fibronectin en
dc.subject proinflammatory cytokine en
dc.subject.classification Medicine, General & Internal en
dc.subject.classification Medicine, Research & Experimental en
dc.subject.other TUMOR-NECROSIS-FACTOR en
dc.subject.other INTERLEUKIN-1 RECEPTOR ANTAGONIST en
dc.subject.other SEPTIC SHOCK en
dc.subject.other SEVERE SEPSIS en
dc.subject.other SERUM en
dc.subject.other DISEASE en
dc.subject.other ENDOTOXIN en
dc.subject.other ASSOCIATION en
dc.subject.other RESISTANCE en
dc.subject.other INFECTION en
dc.title Daily variation in circulating cytokines and acute-phase proteins correlates with clinical and laboratory indices in community-acquired pneumonia en
heal.type journalArticle en
heal.language English en
heal.publicationDate 1997 en
heal.abstract Our objective was to investigate the initial levels of circulating proinflammatory cytokines, such as interleukin 1 beta(IL-1 beta), interleukin 6 (IL-6), and tumour necrosis factor alpha (TNF-alpha), of certain acute-phase proteins, such as C-reactive protein (CRP), fibrinogen (FBN) and albumin, and of the glycoprotein fibronectin at presentation and their daily variation during the clinical course of community-acquired pneumonia (CAP) in relation to clinical and laboratory indices of infection. Thirty otherwise healthy hospitalized patients aged 48 +/- 3 years (mean +/- SEM) and with bacteriologically confirmed CAP were studied prospectively. IL-1 beta and IL-6 were found to be 15-fold higher on admission (122 +/- 9 pg mL(-1) and 60 +/- 4 pg mL(-1) respectively), whereas TNF-alpha was three-fold higher (102 +/- 5 pg mL(-1)) than those of controls, all of them showing a decline towards normal. initial CRP levels were increased 90-fold (416 +/- 1 mg L-1), whereas fibronectin levels were reduced (242 +/- 9 mg dL(-1)). The presence of parapneumonic effusion was associated with a higher TNF-alpha serum level (127 +/- 7 vs. 86 +/- 4 pg mL(-1), P = 0.0002), a more rapid daily decline in TNF-alpha (-7.2 +/- 0.7 vs. -3.8 +/- 0.5 pg mL(-1) day(-1), P = 0.0005), a slower rate of decline in CRP (-42.8 +/- 3.0 vs. -54.6 +/- 3.0 mg L-1 day(-1), P = 0.02) and a slower rate of increase in FBN (5.9 +/- 1.0 vs. 11.7 +/- 1.0 mg dL(-1) day(-1)), P = 0.0011. Furthermore, daily progression of serum levels of cytokines and acute-phase proteins correlated strongly with pyrexia, erythrocyte sedimentation rate CESR), neutrophil count, alveolar-arterial oxygen difference and radiographic resolution, clinically manifested by improvement in the patients' condition. en
heal.publisher BLACKWELL SCIENCE LTD en
heal.journalName EUROPEAN JOURNAL OF CLINICAL INVESTIGATION en
dc.identifier.isi ISI:A1997WV16800009 en
dc.identifier.volume 27 en
dc.identifier.issue 4 en
dc.identifier.spage 308 en
dc.identifier.epage 315 en


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