Daily variation in circulating cytokines and acute-phase proteins correlates with clinical and laboratory indices in community-acquired pneumonia

Kosmas, EN; Baxevanis, CN; Papamichail, M; Kordossis, T

dc.contributor.author	Kosmas, EN	en
dc.contributor.author	Baxevanis, CN	en
dc.contributor.author	Papamichail, M	en
dc.contributor.author	Kordossis, T	en
dc.date.accessioned	2014-03-01T01:46:24Z
dc.date.available	2014-03-01T01:46:24Z
dc.date.issued	1997	en
dc.identifier.issn	0014-2972	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24900
dc.subject	acute-phase proteins	en
dc.subject	community-acquired pneumonia	en
dc.subject	fibronectin	en
dc.subject	proinflammatory cytokine	en
dc.subject.classification	Medicine, General & Internal	en
dc.subject.classification	Medicine, Research & Experimental	en
dc.subject.other	TUMOR-NECROSIS-FACTOR	en
dc.subject.other	INTERLEUKIN-1 RECEPTOR ANTAGONIST	en
dc.subject.other	SEPTIC SHOCK	en
dc.subject.other	SEVERE SEPSIS	en
dc.subject.other	SERUM	en
dc.subject.other	DISEASE	en
dc.subject.other	ENDOTOXIN	en
dc.subject.other	ASSOCIATION	en
dc.subject.other	RESISTANCE	en
dc.subject.other	INFECTION	en
dc.title	Daily variation in circulating cytokines and acute-phase proteins correlates with clinical and laboratory indices in community-acquired pneumonia	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1997	en
heal.abstract	Our objective was to investigate the initial levels of circulating proinflammatory cytokines, such as interleukin 1 beta(IL-1 beta), interleukin 6 (IL-6), and tumour necrosis factor alpha (TNF-alpha), of certain acute-phase proteins, such as C-reactive protein (CRP), fibrinogen (FBN) and albumin, and of the glycoprotein fibronectin at presentation and their daily variation during the clinical course of community-acquired pneumonia (CAP) in relation to clinical and laboratory indices of infection. Thirty otherwise healthy hospitalized patients aged 48 +/- 3 years (mean +/- SEM) and with bacteriologically confirmed CAP were studied prospectively. IL-1 beta and IL-6 were found to be 15-fold higher on admission (122 +/- 9 pg mL(-1) and 60 +/- 4 pg mL(-1) respectively), whereas TNF-alpha was three-fold higher (102 +/- 5 pg mL(-1)) than those of controls, all of them showing a decline towards normal. initial CRP levels were increased 90-fold (416 +/- 1 mg L-1), whereas fibronectin levels were reduced (242 +/- 9 mg dL(-1)). The presence of parapneumonic effusion was associated with a higher TNF-alpha serum level (127 +/- 7 vs. 86 +/- 4 pg mL(-1), P = 0.0002), a more rapid daily decline in TNF-alpha (-7.2 +/- 0.7 vs. -3.8 +/- 0.5 pg mL(-1) day(-1), P = 0.0005), a slower rate of decline in CRP (-42.8 +/- 3.0 vs. -54.6 +/- 3.0 mg L-1 day(-1), P = 0.02) and a slower rate of increase in FBN (5.9 +/- 1.0 vs. 11.7 +/- 1.0 mg dL(-1) day(-1)), P = 0.0011. Furthermore, daily progression of serum levels of cytokines and acute-phase proteins correlated strongly with pyrexia, erythrocyte sedimentation rate CESR), neutrophil count, alveolar-arterial oxygen difference and radiographic resolution, clinically manifested by improvement in the patients' condition.	en
heal.publisher	BLACKWELL SCIENCE LTD	en
heal.journalName	EUROPEAN JOURNAL OF CLINICAL INVESTIGATION	en
dc.identifier.isi	ISI:A1997WV16800009	en
dc.identifier.volume	27	en
dc.identifier.issue	4	en
dc.identifier.spage	308	en
dc.identifier.epage	315	en