Essential trace element alterations in amyotrophic lateral sclerosis

Kapaki, E; Zournas, C; Kanias, G; Zambelis, T; Kakami, A; Papageorgiou, C

dc.contributor.author	Kapaki, E	en
dc.contributor.author	Zournas, C	en
dc.contributor.author	Kanias, G	en
dc.contributor.author	Zambelis, T	en
dc.contributor.author	Kakami, A	en
dc.contributor.author	Papageorgiou, C	en
dc.date.accessioned	2014-03-01T01:46:25Z
dc.date.available	2014-03-01T01:46:25Z
dc.date.issued	1997	en
dc.identifier.issn	0022-510X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/24904
dc.subject	trace elements	en
dc.subject	serum	en
dc.subject	cerebrospinal fluid	en
dc.subject	amyotrophic lateral sclerosis	en
dc.subject	SOD metabolism	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.other	MOTOR-NEURON DISEASE	en
dc.subject.other	CU,ZN SUPEROXIDE-DISMUTASE	en
dc.subject.other	SPINAL-CORD	en
dc.subject.other	NEURODEGENERATIVE DISORDERS	en
dc.subject.other	CEREBROSPINAL-FLUID	en
dc.subject.other	MANGANESE	en
dc.subject.other	COPPER	en
dc.subject.other	MUTATIONS	en
dc.subject.other	SELENIUM	en
dc.subject.other	METALS	en
dc.title	Essential trace element alterations in amyotrophic lateral sclerosis	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1997	en
heal.abstract	Although trace elements have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) for a long time, new evidence has connected familial ALS with the metalloenzyme copper-zinc superoxide dismutase, thus reinforcing the study of their metabolism. This work presents the results of serum and cerebrospinal fluid levels of copper, zinc, manganese and magnesium, by atomic absorption spectrophotometry. Statistically significant decreased cerebrospinal fluid and serum copper levels were found in patients compared to the control group (20.25+/-7.09 vs. 30.86+/-16.02 SD mu g/l and 913.21+/-165.55 vs. 1020.17+/-197.76 SD mu g/l) while serum manganese levels were found to be increased in patients (3.59+/-0.89 SD mu g/l) compared to controls (3.03+/-1.23 SD mu g/l). Zinc and magnesium levels were unchanged. Our findings indicate an essential trace element imbalance in the disease. (C) 1997 Elsevier Science B.V.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	JOURNAL OF THE NEUROLOGICAL SCIENCES	en
dc.identifier.isi	ISI:A1997WR82400009	en
dc.identifier.volume	147	en
dc.identifier.issue	2	en
dc.identifier.spage	171	en
dc.identifier.epage	175	en